Publications

Publication: Scientific Reports

T. D. Turmezei, G. M. Treece, A. H. Gee, S. Sigurdsson, H. Jonsson, T. Aspelund, V. Gudnason & K. E. S. Poole

March 2020


Summary

Hip osteoarthritis is a very common condition that will affect up to 25% of the population in their lifetime. There is no cure for this painful and debilitating disease, with the mainstay of treatment currently being surgical replacement of the joint once it has become too stiff or painful to use. Research trials trying to find effective therapies for osteoarthritis currently rely on x-ray radiograph imaging to test if there have been any meaningful changes in the structure of the joint for a new therapy, but this method suffers from being unable to detect small changes reliably and from only being able to see the joint in 2D.

We developed the joint space mapping (JSM) technique in a collaboration between the Departments of Medicine and Engineering at the University of Cambridge and have since taken it to test on patient data from the widely regarded AGES-Reykjavik patient cohort of healthy older Icelandic adults.

Our research showed that JSM can identify structurally relevant disease features related to the important outcome of joint replacement in hip osteoarthritis better than the current clinical trial 2D imaging gold standards. This means that JSM could be a significantly better way of identifying who might be at high risk from getting hip osteoarthritis, those in whom the disease might be progressing rapidly, and whether any new therapy is effective at stopping the joint destruction that ultimately leads to joint failure. These results have been achieved by using an existing and readily available clinical imaging technique to look at the hip joint in 3D.

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Publication: European Radiology

Caglic I, Brzan PP, Warren A, Bratt O, Shah N, Barrett T.

18 March 2019

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Publication: Clinical Radiology

Gilbert F, Le E, Hickman S, Wang Y, Huang Y.

May 2019

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Publication: Clinical and Translational Oncology

Sushentsev N, Martin H, Rimmer Y, Barrett T.

13 March 2019

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Publication: NeuroImage

Buonincontri G, Biagi L, Retico A, Cecchi P, Cosottini M, Gallagher F, et al.

15 July 2019

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Publication: Journal of the National Cancer Institute

Rodriguez-Ruiz A, Lång K, Gubern-Merida A, Broeders M, Gennaro G, Clauser P, et al.

5 March 2019

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Publication: Insights into Imaging

García-Figueiras R, Baleato-González S, Padhani AR, Luna-Alcalá A, Vallejo-Casas JA, Sala E, et al.

4 March 2019

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Publication: European Radiology.

Zaccagna F, Riemer F, Priest AN, McLean MA, Allinson K, Grist JT, et al.

19 March 2019

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Publication: Journal of Magnetic Reson Imaging

Riemer F, McHugh D, Zaccagna F, Lewis D, McLean MA, Graves MJ, et al.

12 March 2019

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Publication: Lung Cancer

Matys T, Drury R, David S, Rassl DM, Qian W, Rintoul RC, et al. Corrigendum to

10 June 2018

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Publication: Brain

Surendranathan A, Su L, Mak E, Passamonti L, Hong YT, Arnold R, et al.

6 November 2018

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Publication: Brain

Morris RS, Simon Jones P, Alawneh JA, Hong YT, Fryer TD, Aigbirhio FI, et al.

9 May 2018

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Publication: Nature

Nasralla D, Coussios CC, Mergental H, Akhtar MZ, Butler AJ, Ceresa CDL, et al.

18 April 2018

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Publication: Proceedings of National Academy of Sciences

Deniz Vatansever, David K. Menon, and Emmanuel A. Stamatakis

23 October 2017

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Publication: Osteoarthritis and Cartilage

MacKay, J.W., P.J. Murray, B. Kasmai, G. Johnson, S.T. Donell, and A.P. Toms.

13 December 2016

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Publication: PLoS One

Lawrence, E.M., A.Y. Warren, A.N. Priest, T. Barrett, D.A. Goldman, A.B. Gill, V.J. Gnanapragasam, E. Sala, and F.A. Gallagher.

28 July 2016

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Publication: Circulation. Cardiovascular Imaging

Huang, Yuan, Zhongzhao Teng, Maysoon Elkhawad, Jason M. Tarkin, Nikhil Joshi, Jonathan R. Boyle, John R. Buscombe, et al.

10 November 2016

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Publication: Eur Radiol

Hansen, N.L., B.C. Koo, F.A. Gallagher, A.Y. Warren, A. Doble, V. Gnanapragasam, O. Bratt, C. Kastner, and T. Barrett

24 October 2016

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Publication: BJU International

Hansen, Nienke L., Claudia Kesch, Tristan Barrett, Brendan Koo, Jan P. Radtke, David Bonekamp, Heinz-Peter Schlemmer, et al.

10 November 2016

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Publication: BJU International

Hansen, Nienke L., Tristan Barrett, Brendan Koo, Andrew Doble, Vincent Gnanapragasam, Anne Warren, Christof Kastner, and Ola Bratt

4 August 2016

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Publication: Sci Rep

Gnanapragasam, V.J., K. Burling, A. George, S. Stearn, A. Warren, T. Barrett, B. Koo, et al.

17 October 2016

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Publication: NMR in Biomedicine

Daniels, Charlie J., Mary A. McLean, Rolf F. Schulte, Fraser J. Robb, Andrew B. Gill, Nicholas McGlashan, Martin J. Graves, et al.

18 January 2016

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Publication: AJR Am J Roentgenol,

Barrett, T., and M.A. Haider.

January 2017

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Publication: Eur Radiol

Bedair, R., A.N. Priest, A.J. Patterson, M.A. McLean, M.J. Graves, R. Manavaki, A.B. Gill, O. Abeyakoon, J.R. Griffiths, and F.J. Gilbert.

31 October 2016

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