Publications

The latest list of publications from the NIHR Cambridge Biomedical Research Centre with a brief summary. 

If you are publishing research which has had funding and / or support from the NIHR Cambridge Biomedical Research Centre, please complete this form

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Publication: Frontiers in Psychiatry

Rudolf N. Cardinal, Caroline E. Meiser-Stedman,  David M. Christmas,  Annabel C. Price,  Chess Denman,  Benjamin R. Underwood,  Shanquan Chen,  Soumya Banerjee,  Simon R. White,  Li Su,  Tamsin J. Ford,  Samuel R. Chamberlain and  Catherine M. Walsh

25 February 2021


Summary:

Simulated transmission of a COVID-19-like disease in a hypothetical community care team under different conditions.

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Publication: Authorea

Nick K Jones, Lucy Rivett, Chris Workman, Mark Ferris, Ashley Shaw, Paul J LehnerRob HowesGiles WrightNicholas J Matheson, Michael P Weekes

24 February 2020


Summary:

New data from Addenbrooke’s hospital in Cambridge suggests a significant drop in the spread of Covid-19 amongst staff following vaccination. It’s one of the first indications from UK scientists that the Pfizer vaccine reduces the transmission of SARS-CoV-2, the virus that causes Covid-19, as well as protecting people from getting ill. Read the full story.

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Publication: MedRxiV

Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip,  Venexia Walker, Spiros Denaxas, Ashley Akbari, Jonathan Sterne, Cathie Sudlow, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Amitava Banerjee, William Whiteley, Alvina Lai, Rouven Priedon, Cathie Sudlow, Lynn Morrice, Debbie Ringham, Suzannah Power, Lynn Laidlaw, Michael Molete, John Walsh, Garry Coleman, Cath Day, Elizabeth Gaffney, Tim Gentry, Lisa Gray, Sam Hollings, Richard Irvine, Brian Roberts, Estelle Spence, Janet Waterhouse

23 February 2021


Summary:

A new population-wide health data resource to accelerate research on COVID-19 and cardiovascular disease in England.

This work has been led by the CVD-COVID-UK consortium in partnership with NHS Digital. The CVD-COVID-UK consortium is a collaborative group of more than 130 members across 40 institutions working to understand the relationship between COVID-19 and cardiovascular diseases. The consortium is managed by the British Heart Foundation (BHF) Data Science Centre, led by Health Data Research UK.

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Publication: Science

Fotios Sampaziotis, Daniele Muraro, Olivia C. Tysoe, Stephen Sawiak, Timothy E. Beach, Edmund M. Godfrey, Sara S. Upponi, Teresa Brevini, Brandon T. Wesley, Jose Garcia-Bernardo, Krishnaa Mahbubani, Giovanni Canu, Richard Gieseck, Natalie L. Berntsen, Victoria L. Mulcahy, Keziah Crick, Corrina Fear, Sharayne Robinson, Lisa Swift, Laure Gambardella, Johannes Bargehr, Daniel Ortmann, Stephanie E. Brown, Anna Osnato, Michael P. Murphy, Gareth Corbett, William T. H. Gelson, George F. Mells, Peter Humphreys, Susan E. Davies, Irum Amin, Paul Gibbs, Sanjay Sinha, Sarah A. Teichmann, Andrew J. Butler, Teik Choon, Espen Melum, Christopher J. E. Watson, Kourosh Saeb-Parsy, Ludovic Vallier

18 February 2021


Summary:

Researchers in Cambridge have found a way to grow ‘mini bile ducts’ in a lab-setting to repair damaged livers. This new technique could potentially help treat patients whose own livers are not functioning correctly.

Using a recently developed ‘perfusion system’, they were able to transplant biliary cells grown in the lab known as cholangiocytes organoids into damaged human livers to repair them.

This is the first time that a procedure of this kind has been used on human donor organs. It could also increase the number of livers that are considered suitable for organ transplantation and ultimately save more lives.

Read the full story

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Publication: MedRxiV

Martin Wiegand, Sarah L. Cowan, Claire S. Waddington, David J. Halsall,  Victoria L. Keevil,  Brian D. M. Tom, Vince Taylor,  Effrossyni Gkrania-Klotsas, Jacobus Preller,  Robert J. B. Goudie

18 February 2021


Summary

Researchers propose a prognostic dynamic risk stratification for 48-hour in-hospital mortality in patients with COVID-19, using demographics and routinely-collected observations and laboratory tests: age, Clinical Frailty Scale score, heart rate, respiratory rate,

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Publication: ELife

William L Hamilton, Dinesh Aggarwal, Charlotte Houldcroft, Ben Warne, Luke Meredith, Myra Hosmillo, Aminu Jahun,  Laura Caller, Sarah Caddy, Fahad Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte Pinckert, Iliana Georgana, Yasmin Chaudhry, Nicholas Brown, Ewan Harrison,  Gordon Dougan, Sharon Peacock,   Ian Goodfellow,  M. Estee Torok

16 February 2021


Summary:

Approximately 70% of residents in the genomic analysis were admitted to hospital during the study period, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission between care home residents should be a key target for infection control to reduce COVID-19 mortality in this population

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Publication: European Radiology

James W. MacKay, Faezeh Sanaei Nezhad, Tamam Rifai, Joshua D. Kaggie, Josephine H. Naish, Caleb Roberts, Martin J. Graves, John C. Waterton, Robert L. Janiczek, Alexandra R. Roberts, Andrew McCaskie, Fiona J. Gilbert & Geoff J. M. Parker

16 February 2021


Summary

Using a method called dynamic contrast enhancement, where gadolinium contrast is used to detect synovitis (inflammation) in the knee, as a predictor of osteoarthritis. Researchers follow patients for 6-months to detect changes and found it may predict osteoarthritis development.

 

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Publication: OSF Preprints

Christopher J. R. Illingworth,  William L. Hamilton,  Ben Warne, Matthew Routledge, Ashley Popay, Chris Jackson, Tom Fieldman, Luke Meredith, Charlotte J. Houldcroft, Myra Hosmillo, Aminu Jahun, Laura Caller, Sarah Caddy, Anna Yakovleva, Grant Hall, Fahad A. Khokhar, Theresa Feltwell, Malte L. Pinckert, Iliana Georgana, Yasmin Chaudhry, Dominic Sparkes, Lucy Rivett, Nick K. Jones, Sushmita Sridhar, Sally Forrest, Tom Dymond, Kayleigh Grainger, Chris Workman, Effrossyni Gkrania-Klotsas, Nicholas M. Brown, Michael P. Weekes, Stephen Baker, Sharon J. Peacock, Ian Goodfellow, Theodore Gouliouris, Daniela De Angelis, M. Estée Török

15 February 2021


Summary

The SARS-CoV-2 virus has been noted both for its rapid spread, but also for the heterogeneity of transmission, with incidences noted of superspreading behaviour.

Researchers applied a novel network reconstruction algorithm to find patterns of viral transmission occurring between patients and health care workers.

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Publication: Journal of Neurology, Neurosurgery and Psychiatry

Alexander G Murley, Matthew A Rouse, Ian T S Coyle-Gilchrist, P Simon Jones, Win Li, Julie Wiggins, Claire Lansdall, Patricia Vázquez Rodríguez, Alicia Wilcox, Karalyn Patterson, James B Rowe

9 February 2021


Summary

Researchers looked at the clinical features associated with survival in the syndromes related to frontotemporal lobar degeneration, including frontotemporal dementia, progressive suprnuclear palsy and corticobasal syndrome.

They found that behavioural disturbance, including impulsivity and apathy, is associated with reduced functionally independent survival.

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Publication: Stroke Aha

Eric L. Harshfield, Marios K. Georgakis, Rainer Malik, Martin Dichgans, Hugh S. Markus

4 February 2021


Summary

Assessing whether modifiable risk factors are causally associated with stroke risk.

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Publication: Geriatrics

Christopher N. Osuafor, Catriona Davidson, Alistair J. Mackett, Marie Goujon, Lelane Van Der Poel, Vince Taylor, Jacobus Preller, Robert J. B. Goudie and Victoria L. Keevil

1 February 2021


Summary

In an observational study, researchers in Cambridge investigated the clinical features and inpatient trajectories of older adults hospitalised with COVID-19 and explore relationships with frailty.

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Publication: Neurobiology of Ageing

ElijahMaka, NeginHolland, P. Simon Jones, George Savulich, Audrey Lowa, Maura Malpetti, Sanne Kaalund, Luca Passamonti, Timothy Rittman, Rafael Romero-Garciaa, Roido Manavakic, Guy B.Williams, Young T.Hong, Ti m D. Fryerb, Franklin I. Aigbirhio, John O’Brien, James Rowe

30 January 2021


Summary

Researchers found in neurodegenerative disorders of Progressive Supranuclear Palsy and Corticobasal Degeneration, the core communication units of the brain (present on nerve cell ‘bodies’ and ‘tails’) are tightly coupled together and are both significantly reduced by the disease process. The research shows changes in the brain of patients with neurodegenerative disorders and can help inform the design of clinical trials

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