Publications

Publication: BMC Medicine

Ju-Sheng Zheng, Stephen J. Sharp, Fumiaki Imamura, Albert Koulman, Matthias B. Schulze, Zheng Ye, Jules Griffin, Marcela Guevara, José María Huerta, Janine Kröger, Ivonne Sluijs, Antonio Agudo, Aurelio Barricarte, Heiner Boeing, Sandra Colorado-Yohar, Courtney Dow, Miren Dorronsoro, Pia T. Dinesen, Guy Fagherazzi, Paul W. Franks, Edith J. M. Feskens, Tilman Kühn, Verena Andrea Katzke, Timothy J. Key, Kay-Tee Khaw, Maria Santucci de Magistris, Francesca Romana Mancini, Elena Molina-Portillo, Peter M. Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Jose Ramón Quirós, Olov Rolandsson, Fulvio Ricceri, Annemieke M. W. Spijkerman, Nadia Slimani, Giovanna Tagliabue, Anne Tjonneland, Rosario Tumino, Yvonne T. van der Schouw, Claudia Langenberg, Elio Riboli, Nita G. Forouhi & Nicholas J. Wareham

17 November 2017

Summary

Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways.

Publication: The Lancet Neurology

Prof Andrew I R Maas, Prof David K Menon, P David Adelson, Nada Andelic, Michael J Bell, Antonio Belli et al.

6 November 2017

Publication: BMJ Open

Price A, Farooq R, Yuan J-M, Menon VB, Cardinal RN, O’Brien JT

3 November 2017

The researchers here aimed to use routine clinical data to investigate survival in dementia with Lewy bodies (DLB) compared with Alzheimer’s dementia (AD).

DLB is the second most common dementia subtype after AD, accounting for around 7% of dementia diagnoses in secondary care, though studies suggest that it is underdiagnosed by up to 50%.

Most previous studies of DLB have been based on select research cohorts, so little is known about the outcome of the disease in routine healthcare settings.

Working with Cambridgeshire & Peterborough NHS Foundation Trust, a mental health trust providing secondary mental health care in England, the researchers used samples from 251 DLB and 222 AD identified from an anonymised database, derived from electronic clinical case records across an 8-year period (2005-2012), with mortality data updated to May 2015.

Raw (uncorrected) median survival was 3.72 years for DLB and 6.95 years for AD. Controlling for age at diagnosis, comorbidity and antipsychotic prescribing the model predicted median survival for DLB was 3.3 years for males and 4.0 years for females, while median survival for AD was 6.7 years for males and 7.0 years for females.

The researchers concluded that survival from first presentation with cognitive impairment was markedly shorter in DLB compared with AD, independent of age, sex, physical comorbidity or antipsychotic prescribing.

This finding, in one of the largest clinical cohorts of DLB cases assembled to date, adds to existing evidence for poorer survival for DLB versus AD. There is an urgent need for further research to understand possible mechanisms accounting for this finding.

Publication: The New England Journal of Medicine

Marcovecchio ML, Chiesa ST, Bond S, Daneman D, Dawson S, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dalton RN, Deanfield J, Dunger DB; AdDIT Study Group

2 November 2017

Publication: J Neurol

Underwood BR, Green-Thompson ZW, Pugh PJ, Lazic SE, Mason SL4, Griffin J, Jones PS, Rowe JB, Rubinsztein DC7,4, Barker RA.

26 October 2017

Publication: Proceedings of National Academy of Sciences

Deniz Vatansever, David K. Menon, and Emmanuel A. Stamatakis

23 October 2017

Publication: PLoS Med

Imamura F, Sharp SJ, Koulman A, Schulze MB, Kroger J, Griffin JL, et al.

11 Oct 2017

Summary

Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated.

Publication: Nature

Norah M. E. Fogarty, Afshan McCarthy, Kirsten E. Snijders, Benjamin E. Powell, Nada Kubikova, Paul Blakeley, Rebecca Lea, Kay Elder, Sissy E. Wamaitha, Daesik Kim, Valdone Maciulyte, Jens Kleinjung, Jin-Soo Kim, Dagan Wells, Ludovic Vallier, Alessandro Bertero10, James M. A. Turner & Kathy K. Niakan

20 September 2017

Publication: The Lancet

Emanuele Di Angelantonio, Prof Simon G Thompson, Stephen Kaptoge, Carmel Moore, Matthew Walker, Prof Jane Armitage, Prof Willem H Ouwehand, Prof David J Roberts, Prof John Danesh

20 September 2017

Publication: Cell

C.A. Madigan, C.J. Cambier, K.M. Kelly-Scumpia, P.O. Scumpia, T.Y. Cheng, J. Zailaa, B.R. Bloom, D.B. Moody, S.T. Smale, A. Sagasti, R.L. Modlin, L. Ramakrishnan.

24 August 2017

Publication: Nature

Burr ML, Sparbier CE, Chan-YC, Williamson JC, Woods K, Beavis P,Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Noori T, Morgens D, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson S-J, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ^†, Dawson MA^†.

16 August 2017

Publication: Cell

Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W, Clatworthy MR.

10 August 2017

Publication: International Journal of Neuropsychopharmacology

Publication: Clinical Nutrition Journal

Laura O’Connor, Fumiaki Imamura, Soren Brage, Simon J. Griffin, Nicholas J. Wareham, Nita G. Forouhi

June 2017

Summary

Associations of dietary sugars with metabolic and inflammatory markers may vary according to the source of the sugars. The aim of this study was to examine the association of dietary sugars from different sources [beverages (liquids), foods (solids), extrinsic (free) or intrinsic (non-free)] with metabolic and inflammatory markers.

Publication: The American Journal of Clinical Nutrition,

Sherly X Li, Fumiaki Imamura, Zheng Ye, Matthias B Schulze, Jusheng Zheng, Eva Ardanaz, Larraitz Arriola, Heiner Boeing, Courtney Dow, Guy Fagherazzi, Paul W Franks, Antonio Agudo, Sara Grioni, Rudolf Kaaks, Verena A Katzke, Timothy J Key, Kay Tee Khaw, Francesca R Mancini, Carmen Navarro, Peter M Nilsson, N Charlotte Onland-Moret, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, María-José Sánchez, Nadia Slimani, Ivonne Sluijs, Annemieke MW Spijkerman, Anne Tjonneland, Rosario Tumino, Stephen J Sharp, Elio Riboli, Claudia Langenberg, Robert A Scott, Nita G Forouhi, Nicholas J Wareham

7 June 2017

Summary

Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date.

Researchers aimed to identify existing evidence for gene-macronutrient interactions and T2D and to examine the reported interactions in a large-scale study.

Publication: Nature Genetics

Tchasovnikarova IA, Timms RT, Douse DH, Roberts RC, Dougan G, Kingston RE Modis Y, Lehner PJ .

5 June 2017

Publication: Nutrition Journal 

Oonagh Markey, Dafni Vasilopoulou, Kirsty E. Kliem, Albert Koulman, Colette C. Fagan, Keith Summerhill, Laura Y. Wang, Alistair S. Grandison, David J. Humphries, Susan Todd, Kim G. Jackson, David I. Givens & Julie A. Lovegrove

23 May 2017

Summary

Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet.

To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status.

Publication: Global Health, Epidemiology and Genomics

Allcock S, Young EH, Holmes M, Gurdasani D, Dougan G, Sandhu MS, Solomon L, Török ME.

10 May 2017

Publication: BMC Medical Informatics and Decision Making

Rudolf N Cardinal

26 April 2017

Electronic medical records contain information of value for research, but contain identifiable and often highly sensitive confidential information.

Patient-identifiable information cannot in general be shared outside clinical care teams without explicit consent, but anonymisation/de-identification allows research uses of clinical data without explicit consent.

This article presents CRATE (Clinical Records Anonymisation and Text Extraction), an open-source software system with separable functions: (1) it anonymises or de-identifies arbitrary relational databases, with sensitivity and precision similar to previous comparable systems; (2) it uses public secure cryptographic methods to map patient identifiers to research identifiers (pseudonyms); (3) it connects relational databases to external tools for natural language processing; (4) it provides a web front end for research and administrative functions; and (5) it supports a specific model through which patients may consent to be contacted about research.

Creation and management of a research database from sensitive clinical records with secure pseudonym generation, full-text indexing, and a consent-to-contact process is possible and practical using entirely free and open-source software.

Publication: Nature

Danish Saleheen, Pradeep Natarajan, Irina M. Armean, Wei Zhao, Asif Rasheed, Sumeet A. Khetarpal, Hong-Hee Won, Konrad J. Karczewski, Anne H. O’Donnell-Luria, Kaitlin E. Samocha, Benjamin Weisburd, Namrata Gupta, Mozzam Zaidi, Maria Samuel, Atif Imran, Shahid Abbas, Faisal Majeed, Madiha Ishaq, Saba Akhtar, Kevin Trindade, Megan Mucksavage, Nadeem Qamar, Khan Shah Zaman, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Nadeem Hayyat Mallick, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Khalid Mahmood, Naveeduddin Ahmed,   Ron Do, Ronald M. Krauss, Daniel G. MacArthur, Stacey Gabriel,  Eric S. Lander, Mark J. Daly, Philippe Frossard, John Danesh, Daniel J. Rader  & Sekar Kathiresan

12 April 2017