Publications

Publication: Diabetes Care

Karina Meidtner, Clara Podmore, Janine Kröger, Yvonne T. van der Schouw, Benedetta Bendinelli, Claudia Agnoli, Larraitz Arriola, Aurelio Barricarte, Heiner Boeing, Amanda J. Cross, Courtney Dow, Kim Ekblom, Guy Fagherazzi, Paul W. Franks, Marc J. Gunter, José María Huerta, Paula Jakszyn, Mazda Jenab, Verena A. Katzke, Timothy J. Key, Kay Tee Khaw, Tilman Kühn, Cecilie Kyrø, Francesca Romana Mancini, Olle Melander, Peter M. Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J. Ramón Quirós, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Ivonne Sluijs, Magdalena Stepien, Anne Tjonneland, Rosario Tumino, Nita G. Forouhi, Stephen J. Sharp, Claudia Langenberg, Matthias B. Schulze, Elio Riboli and Nicholas J. Wareham

February 2018

Summary

Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. Researchers aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.

Publication: Brain

Newton T, Allison R, Edgar JR, Lumb JH, Rodger CE, Manna PT, et al.

22 February 2018

Publication: American Society for Microbiology

Klemm EJ, Shakoor S, Page AJ, Qamar FN, Judge K, Saeed DK, Wong VK, Dallman TJ, Nair S, Baker S, Shaheen G, Qureshi S, Yousafzai MT, Saleem MK, Hasan Z, Dougan G, Hasan R

20 February 2018

Publication: Digestive Diseases and Sciences

Kiely CJ, Clark A, Bhattacharyya J, Moran GW, Lee JC, Parkes M.

19 February 2018

Publication: American Journal of Transplantation

Watson CJE, Kosmoliaptsis V, Pley C, Randle L, Fear C, Crick K, et al.

8 February 2018

Publication: Pediatric Diabetes

Claire M Nightingale, Alicja R Rudnicka, Sarah R Kerry-Barnard, Angela S Donin, Soren Brage, Kate L Westgate, Ulf Ekelund, Derek G Cook, Christopher G Owen, Peter H Whincup

07 February 2018

Summary

The relationship between physical fitness and risk markers for type 2 diabetes (T2D) in children and the contribution to ethnic differences in these risk markers have been little studied. Researchers examined associations between physical fitness and early risk markers for T2D and cardiovascular disease in 9- to 10-year-old UK children.

Publication: Surgery for obesity and related diseases

Roberts GP, Kay RG, Howard J, Hardwick RH, Reimann F, Gribble FM.

2 February 2018

Publication: Annals

Linda M. O’Keeffe, PhD; Anna Ramond, DPharm; Clare Oliver-Williams, PhD; Peter Willeit, MD; Ellie Paige, PhD; Patrick Trotter, MBChB; Jonathan Evans, MBChB; Jonas Wadström, MD; Michael Nicholson, MD; Dave Collett, PhD; Emanuele Di Angelantonio, MD

30 January 2018

Summary:

Living kidney donors are not at increased risk for some health outcomes previously of concern, but do seem at risk for worse blood pressure and kidney function than nondonors. In addition, female donors seem to be at increased risk for preeclampsia.

A team lead by researchers reviewed 52 published studies comprising more than 100,000 living kidney donors and more than 110,000 nondonors to assess the mid- and long-term health risks associated with living kidney donation in adults.

The data showed that kidney donors had higher diastolic blood pressure, poorer renal function, and higher risk for ESRD than nondonors. Female donors had an almost two-fold higher risk than nondonors for pregnancy-related complications, such as preeclampsia.

There was no evidence that living kidney donors had higher risk for mortality, cardiovascular disease, or type 2 diabetes, or reduced quality of life.

Publication: Brain

Smets I, Fiddes B, Garcia-Perez JE, He D, Mallants K, Liao W, et al.

18 January 2018

Publication: Nature Cell Biology

Vasileios I. Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred W. C. Tang, Naoko Irie, Brendan Payne, Antonio Capalbo, Laila Noli, Jonathan Coxhead, Gavin Hudson, Moira Crosier, Henrik Strahl, Yacoub Khalaf, Mitinori Saitou, Dusko Ilic, M. Azim Surani & Patrick F. Chinnery

15 January 2018

Summary:

Researchers have shown for the first time how children can inherit a severe – potentially fatal – mitochondrial disease from a healthy mother. The study reveals that healthy people harbour mutations in their mitochondrial DNA and explains how cases of severe mitochondrial disease can appear unexpectedly in previously unaffected families.

Mitochondrial diseases caused by mutations in mitochondrial DNA are rare, affecting approximately 1 in 10,000 births, but can cause severe conditions. Mitochondria are the powerhouses inside our cells, producing energy and carrying their own DNA instructions (separate from the DNA in the nucleus of every cell) and are inherited from a person’s mother via the egg.

In this study, the researchers found that a variety of mutations were present in the mitochondrial DNA in the developing egg cells of all 12 of the human embryos studied, showing that low levels of mitochondrial DNA mutations are carried by healthy humans.

Publication: European Journal of Epidemiology

Nicholas R. V. Jones,  Nita G. Forouhi, Kay-Tee Khaw,  Nicholas J. Wareham &  Pablo Monsivais

9 January 2018

Summary

The dietary approaches to stop hypertension (DASH) diet could be an important population-level strategy to reduce cardiovascular disease (CVD) in the UK, but there is little UK-based evidence on this diet pattern in relation to CVD risk.

Researchers tested whether dietary accordance with DASH was associated with risk of CVD in a population-based sample of 23,655 UK adults.

Publication: Brain

Thomas E Cope, Timothy Rittman, Robin J Borchert, P Simon, JonesDeniz Vatansever, Kieren Allinson Luca Passamonti, Patricia Vazquez Rodriguez, W Richard Bevan-Jones, John T O’Brien, James B Rowe

Publication: PLOS Medicine

Oliver T. Mytton, Nita G. Forouhi, Peter Scarborough, Marleen Lentjes, Robert Luben, Mike Rayner, Kay Tee Khaw, Nicholas J. Wareham, Pablo Monsivais

4 January 2018

Summary

In the United Kingdom, the Food Standards Agency-Ofcom nutrient profiling model (FSA-Ofcom model) is used to define less-healthy foods that cannot be advertised to children. However, there has been limited investigation of whether less-healthy foods defined by this model are associated with prospective health outcomes. The objective of this study was to test whether consumption of less-healthy food as defined by the FSA-Ofcom model is associated with cardiovascular disease (CVD)

Publication: Molecular Neurobiology

Galindo L, Moreno E, Lopez-Armenta F, Guinart D, Cuenca-Royo A, Izquierdo-Serra M, et al.

2 January 2018

Publication: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.

Mak E, Bethlehem RA, Romero-Garcia R, Cervenka S, Rittman T, Gabel S, Surendranathan A, Bevan-Jones RW, Passamonti L, Rodríguez PV, Su L.

1 January 2018

Publication: International Journal of Behavioral Nutrition and Physical Activity

Alessandra Prioreschi, Soren Brage, Kylie D. Hesketh, Jill Hnatiuk, Kate Westgate & Lisa K. Micklesfield

22 December 2017

Summary

Physical activity is considered to have health benefits across the lifespan but levels, patterns, and correlates have not been well described in infants and toddlers under the age of two years. This study aimed to describe objectively and subjectively measured physical activity in a group of South African infants aged 3- to 24-months.

Publication: Diabetic Medicine

Thabit H, Hovorka R.

21 December 2017

Publication: Trop Medicine International Health

Esther Babirekere-Iriso, Maren Johanne Heilskov Rytter, Hanifa Namusoke, Ezekiel Mupere, Kim F. Michaelsen, Ken D. Stark, Lotte Lauritzen, André Briend, Henrik Friis, Søren Brage, Daniel Faurholt-Jepsen

13 December 2017

Summary

To assess the level and predictors of physical activity at discharge among children recovering from severe acute malnutrition (SAM).

Publication: Lancet Diabetes Endocrinology

Jason H Y Wu, Matti Marklund,  Fumiaki Imamura, Nathan Tintle, Andres V Ardisson Korat, Janette de Goede,  Xia Zhou,  Wei-Sin Yang,  Marcia C de Oliveira Otto,  Janine Kröger, Waqas Qureshi,  Jyrki K Virtanen,  Julie K Bassett,  Alexis C Frazier-Wood,  Maria Lankinen,  Rachel A Murphy,  Kalina Rajaobelina,  Liana C Del Gobbo,  Nita G Forouhi,  Robert Luben,  Kay-Tee Khaw, Nick Wareham, Anya Kalsbeek, ,Jenna Veenstra, Juhua Luo,  Frank B Hu,  Hung-Ju Lin,  David S Siscovick,  Heiner Boeing,  Tzu-An Chen,  Brian Steffen,  Lyn M Steffen,  Allison Hodge,  Gudny Eriksdottir,  Albert V Smith,  Vilmunder Gudnason,  Tamara B Harris,  Ingeborg A Brouwer,  Claudine Berr,  Catherine Helmer,  Cecilia Samieri,  Markku Laakso,  Michael Y Tsai,  Graham G Giles,  Tarja Nurmi,  Lynne Wagenknecht, Matthias B Schulze, Rozenn N Lemaitre,  Kuo-Liong Chien,  Sabita S Soedamah-Muthu,  Johanna M Geleijnse,  Qi Sun,  William S Harris,  Lars Lind,  Johan Ärnlöv,  Ulf Riserus, Renata Micha,  Dariush Mozaffarian,  for theCohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE)

01 December 2017

Summary

The metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.

Publication: Lancet

Schormair, B., Zhao, C., Bell, S. et al.

November 2017

Summary:

A new study into the genetics underlying restless legs syndrome has identified 13 previously-unknown genetic risk variants, while helping inform potential new treatment options for the condition.

Studies of families and twins have shown that there is a strong genetic component to the disorder and led to the discovery of six genetic variants that increased the risk of developing the condition.