Publications

Publication: BMJ Open

John OO Ayorinde, Dominic M Summers, Laura Pankhurst, Emma Laing, Alison J Deary, Karla Hemming, Edward CF Wilson, Victoria Bardsley, Desley A Neil, Gavin J Pettigrew

17 January 2019

Summary:

Most potential kidney transplant donors in the UK are aged over 60 years, yet increasing donor age is associated with poorer graft survival and function. Urgent preimplantation kidney biopsy can identify chronic injury, and may aid selection of better ‘quality’ kidneys from this group. However, the impact of biopsy on transplant numbers remains unproven. The PreImplantation Trial of Histopathology In renal Allografts (PITHIA) study will assess whether the introduction of a national, 24 hours, digital histopathology service increases the number, and improves outcomes, of kidneys transplanted in the UK from older deceased donors.

Publication: Diabetes Care

Lowe WL Jr, Scholtens DM, Kuang A, Linder B, Lawrence JM, Lebenthal Y, McCance D, Hamilton J, Nodzenski M, Talbot O, Brickman WJ, Clayton P, Ma RC, Tam WH, Dyer AR, Catalano PM, Lowe LP, Metzger BE;

17 January 2019

Publication: Cell

van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS.

17 January 2019

Publication: Pediatric Diabetes

Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R. .

16 January 2019

Publication: Nature Reviews

Monk D, Mackay DJG, Eggermann T, Maher ER, Riccio A.

15 January 2019

Publication: Genetics in Medicine

Lee A, Mavaddat N, Wilcox AN, Cunningham AP, Carver T, Hartley S, Babb de Villiers C, Izquierdo A, Simard J, Schmidt MK, Walter FM, Chatterjee N, Garcia-Closas M, Tischkowitz M, Pharoah P, Easton DF, Antoniou AC.

15 January 2019

Publication: JAMA

Brown JWL, Coles A, Horakova D, Havrdova E, Izquierdo G, Prat A et al.

15 January 2019

Publication: Stroke

Drazyk AM, Tan RYY, Tay J, Traylor M, Das T, Markus HS.

14 January 2019

Publication: Journal of Hepatology

Rhiannon Taylor, Elisa Allen, James A. Richards, Mingzheng A. Goh, James Neuberger, David Collett, Gavin J. Pettigrew, Liver Advisory Group to NHS Blood and Transplant

11 January 2019

Summary:

This study looks at patients who require a liver transplant to save their lives; this liver can be donated by a person who has died either after their heart has stopped (donation after cardiac death – DCD) or after the brain has been injured and can no longer support life (donation after brainstem death – DCB). We know that livers donated after brainstem death function better than those after cardiac death, but there are not enough of these livers for everyone, so we wished to help patients decide whether it was better for them to accept an early offer of a DCD liver than waiting longer to receive a “better” liver from a DBD donor. We found that patients were more likely to survive if they accepted the offer of a liver transplant as soon as possible (DCD or DBD), especially if their liver disease was very severe.

Publication: Diabetes Care

Scholtens DM, Kuang A, Lowe LP, Hamilton J, Lawrence JM, Lebenthal Y, Brickman WJ, Clayton P, Ma RC, McCance D, Tam WH, Catalano PM, Linder B, Dyer AR, Lowe WL Jr, Metzger BE; HAPO Follow-Up Study Cooperative Research Group.

7 January 2019

Publication: Annals of Clinical Translational Neurology

Bevan-Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer T, et al.

2 January 2019

Publication: Science Signalling

Schneditz G, Elias JE, Pagano E, Zaeem Cader M, Saveljeva S, Long K, Mukhopadhyay S, Arasteh M, Lawley TD, Dougan G, Bassett A, Karlsen TH, Kaser A, Kaneider NC.

1 January 2019

Publication: Psychological Medicine

Fernandez-Egea E, Worbe Y, Bernardo M, Robbins TW.

December 2018

Publication: Clinical Endicrinology

Wong MY, Andrews KA, Challis BG, Park SM, Acerini CL, Maher ER, et al.

27 December 2018

Publication: JAMA Network

Lotta LA, Wittemans LBL, Zuber V, Stewart ID, Sharp SJ, Luan J, et al.

25 December 2018

The distribution of body fat is associated with the propensity of overweight individuals to manifest insulin resistance and its associated metabolic and cardiovascular complications.

The waist-to-hip ratio (WHR) is a widely used, convenient, and robustly validated indicator of fat distribution and is linked to the risk of type 2 diabetes and coronary disease independently of body mass index (BMI).

This observation has been used to infer that accumulation of fat in the abdominal cavity is an independent causal contributor to cardiometabolic disease. While many studies support this assertion and plausible mechanisms have been proposed, WHR can also be increased by a reduction in its denominator, the hip circumference.

Evidence from several different forms of partial lipodystrophy and functional studies of peripheral adipose storage compartments suggests that a primary inability to expand gluteofemoral or hip fat can also underpin subsequent cardiometabolic disease risk.

Emerging evidence from the analysis of common genetic variants associated with greater insulin resistance but lower levels of hip fat suggests that similar mechanisms may also be relevant to the general population.

In this study, large-scale human genetic data were used to investigate whether genetic variants related to body fat distribution via lower levels of gluteofemoral (hip) fat or via higher levels of abdominal (waist) fat are associated with type 2 diabetes or coronary disease risk.

Publication: Hepatology

Goode EC, Clark AB, Mells GM, Srivastava B, Spiess K, Gelson WTH, et al.

19 December 2018

Publication: European Journal of Human Genetics

Nixon TRW, Richards A, Towns LK, Fuller G, Abbs S, Alexander P, et al.

19 December 2018

Publication: Proceedings of the National Academy of Sciences USA

Klemm EJ, Wong VK, Dougan G.

18 December 2018

Publication: Clinical Gastroenterology Hepatology

Hegade VS, Mells GF, Fisher H, Kendrick S, DiBello J, Gilchrist K, et al.

14 December 2018

Publication: European Respiratory Journal

Nathan SD, Barbera JA, Gaine SP, Harari, S, Martinez FJ, Olschewski H, Olsson KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Werner Seeger W.

13 December 2018