SMCL Next Generation Sequencing (NGS) Hub

The Stratified Medicine Core Laboratory (SMCL) NGS Hub is involved in world class sequencing research partnerships with clients both within the University of Cambridge and the Cambridge University Hospital NHS Foundation Trust, along with further external Academic and Commercial organisations.

The SMCL NGS Hub aims to provide a comprehensive and expert Next Generation Sequencing service to the academic, clinical & commercial community, with the distinctive mission of providing a clinical translational service.

The SMCL NGS Hub is hosted by the Department of Medical Genetics of the University of Cambridge and, uniquely, housed in the Medical Genetics Laboratories of the East Midlands and East of England NHS Genomic Laboratory Hub (East GLH), allowing us to offer researchers access to clinical grade next generation sequencing services.

What can SMCL offer to the academic, clinical and commercial communities?

  • SMCL offers researchers access to clinical grade next generation sequencing; a range of platforms to suit all budgets and coverage requirements at short turnaround times.
  • SMCL can provide a complete ‘end to end’ service with a fully flexible approach, encompassing nucleic acid extraction and sample QC, full library preparation and sequencing and bioinformatics analysis or support (or individual parts of this pathway).
  • SMCL also offers advice on experimental and project design, and can tailor services (e.g., bespoke NGS assays) to specific project needs.
  • SMCL’s typical services include:
    • Extraction services
    • Library Prep
    • Clinical Grade Whole Genome Sequencing
    • Clinical Grade Whole Exome Sequencing
    • Clinical Grade Targeted Sequencing
    • RNA-SEQ
    • Epigenetic analysis (targeted methylation assays, genome wide methylation profiling, RRBS).
  • SMCL equipment
    • Illumina sequencers
    • Illumina cBot
    • Agilent Tapestation
    • QIAGEN QIAsymphony
    • Beckman Coulter Biomek FXP
    • Covaris E220 Focused Ultrasonicator

Please visit SMCL website for further details about the facility’s services and equipment.

For quotes and general enquiries, please contact SMCL by email.

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