NIHR Cambridge BRC-funded research is top-five most-cited in world-leading general cardiology publication

Research from the University of Cambridge’s Cardiovascular Epidemiology Unit and funded by NIHR Cambridge BRC are listed in the top five most-cited papers in the European Heart Journal over 2023.

Occupying top spot is the research paper Mendelian randomization for cardiovascular diseases: principles and applications by authors Stephen Burgess, Adam Butterworth and collaborator Susanna Larsson. Their review describes the principles of the Mendelian randomization design and its applications in cardiovascular epidemiology, explaining the jargon, assumptions, advantages, caveats and limitations.

In fourth place is SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe, from researchers Lisa Pennells, Stephen Kaptoge and Emanuele Di Angelantonio.

This is a new risk calculator that will help to identify people with type 2 diabetes more accurately, according to country of residence, who are at high risk of developing heart and circulatory diseases in the next 10 years.

Director of the NIHR Cambridge BRC, Professor Miles Davies, said: “This is a major achievement, especially given the translational relevance of both Mendelian randomisation (particularly for drug development and repurposing) and SCORE2-Diabetes. Congratulations to all investigators involved!”