Data Science and Population Health

This Theme’s Focus

Genomics in healthcare
Therapeutic target prioritisation
Addressing multiple long-term conditions through data-driven studies
Risk prediction and screening

Large population studies investigating the links between genetics and disease, such as the 100,000 Genomes Project, NIHR BioResource and the UK BioBank have created huge amounts of data on health and disease and further studies large and small continue to create valuable data every day. The rapidly increasing availability of complex health data provides an exceptional opportunity to transform health outcomes at individual and population levels as well as to enhance healthcare efficiency.

The goal of the Data Science and Population Health theme is to make use of these enormous amounts of data to improve early detection and prevention of heart attacks, strokes, dementia, infections and cancers in the UK over the next decade. Working with other themes across the NIHR Cambridge BRC, we will develop, evaluate and distribute complementary computational systems and tools that can identify and interpret important, usable patterns hidden in large, diverse and constantly growing biomedical data sets.

Our efforts and tools will help us to understand the early origins of disease, identify promising targets for intervention and untangle the complexities of multiple long-term conditions, ultimately improving the lives.

We are building the infrastructure, expertise and oversight framework that will allow us to maintain and enhance our international leadership in this field, as well as reflect our strong values: promoting equity and avoiding bias in healthcare, embedding patients and public representatives in our leadership and operational structures, and ensuring our research benefits underserved and marginalised communities.

We work highly collaboratively with partners like, i.e. EMBL-European Bioinformatics Institute (key partner for initiatives like the Polygenic Risk Score Catalog) and Health Data Research UK (in particular, the Molecules to Health Records and Big Data for Complex Disease Driver Programmes).

Theme Leads

Michael Inouye

Professor of Systems Genomics & Population Health
Email: mi336@medschl.cam.ac.uk

Professor Angela Wood

Professor of Health Data Science in the Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Cambridge.
Email: amw79@medschl.cam.ac.uk

Meet our researchers

The Data Science and Population Health theme will address two overarching research questions:

How can research in biostatistics, machine learning and artificial intelligence (AI) be used equitably and at scale to improve healthcare in diverse settings?

How can a “molecule to e-health record” strategy combining multiple kinds information (such as genetics, imaging, test results and health records) from millions of UK individuals, improve understanding, treatment and prediction of multiple long-term conditions?

For more Information

You can watch previous talks from our research teams on YouTube.

Read about ‘Behind the Curtain’ where a piece of research was turned into theatrical production and post-show discussion looking at the health information hidden in your DNA. The piece is available to watch online or you can read the paper.

Working with patients and the public

Researchers in this theme work closely with patients and members of the public to strengthen lay participation in their research.

Listen to the podcast below for the latest in Health Data Insights.
The theme has its own PPIE group. If you’d like to find out more about this or would like to join, please click on our Ongoing PPIE Opportunities page for contact details.

Podcast: Health Data Science Insights – Cambridge

Passionate about transforming health, researchers from Population Health and Data Science are hosting a podcast for health data science researchers and the public called ‘Health Data Science Insights – Cambridge’. Based in the Cardiovascular Epidemiology Unit at the University of Cambridge, they collaborate nationally and internationally and explore topics like Trusted Research Environments, ethical considerations, AI and multiomics.

Join Dr Alexia Sampri, Dr Elena Raffetti, Dr Elias Allara as they engage with leading experts and explore all things health data science.

You can listen to the ‘Health Data Science Insights – Cambridge’ podcast on popular platforms like Apple Podcasts Spotify and Podscan

Latest News

Genomics lab reading samples - NIHR Cambridge BRC image

Research collaboration offers new polygenic score insights in type 2 diabetes and related co-morbidities

March 11, 2025

An on-campus collaboration between NIHR Cambridge BRC-funded…

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Polygenic Score Catalog increases diversity and usability of genetic data

October 3, 2024

A paper highlighting changes to the Polygenic Score (PGS)…

Photo by National Cancer Institute on unsplash.com

‘Gene misbehaviour’ widespread in healthy population

July 25, 2024

NIHR Cambridge BRC researchers have been involved in…

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Prestigious NIHR Research Professorship awarded to Cambridge researcher

November 23, 2023

Congratulations to co-theme lead for the NIHR Cambridge BRC Data Science and Population Health theme, Professor Angela Wood, who has been awarded an NIHR research professorship.

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Cambridge researchers listed among world’s most influential researchers

November 21, 2022

Congratulations to our NIHR Cambridge BRC theme leads who have been named in the Clarivate listings of the ‘world’s most influential researchers.’

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World first for AI and machine learning to treat Covid patients worldwide

September 15, 2021

Researchers across the world have used artificial intelligence to predict Covid patients’ oxygen needs on a global scale.

Previous Next

Data Science and Population Health Case Studies

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Predicting risk of cancer, heart attacks and other diseases using DNA

October 16, 2024

The human genome (the complete set of genetic information in…

Image of risk calculator to predict risk of heart attack and stroke

New risk calculators to predict people at high risk of heart attacks and stroke

October 16, 2024

Cambridge-led working groups and the European Society of…

Informing healthcare policy with COVID-19 data

October 16, 2024

The SARS-CoV-2 virus has resulted in more than 235 million…

Screening and Treatment for Abdominal Aortic Aneurysm

October 16, 2024

Cambridge researchers led a randomised trial to see whether…

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Reviewing the NHS Health Check programme

October 16, 2024

The NHS Health Check programme was introduced across England…

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Data Science and Population Health Publications

Using machine learning to model older adult inpatient trajectories from electronic health records data

January 17, 2023

Factors Associated with Significant Weight Loss in Hospitalised Patients with COVID-19: A Retrospective Cohort Study in a Large Teaching Hospital

November 23, 2022

Unquantifiably low aldosterone concentrations are prevalent in hospitalised COVID-19 patients but may not be revealed by chemiluminescent immunoassay

August 30, 2022

Difficulty and help with activities of daily living among older adults living alone during the COVID-19 pandemic: a multi-country population-based study

March 31, 2022

Validation of the 4C Deterioration Model for COVID-19 in a UK teaching hospital during Wave 2

November 16, 2021

The NIHR Cambridge BRC is part of the NIHR and hosted by Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge. We are at the heart of the Cambridge Biomedical Campus, Europe’s largest health research area.

Contact Us

Cambridge Biomedical Research Centre
Box 277
Hills Road
Cambridge
CB2 0QQ

Tel: 01223 348490

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Research at CPFT @cpft_research ·

13 Apr

🗓️ Join this free regional research event to learn about the @NIHRresearch Insight programme on Wednesday 13 May, 10am to 5pm.
🔎 Find out how to apply to start #YourPathInResearch and meet researchers in the #EastofEngland.
Register your free place here ➡️https://www.eventbrite.co.uk/e/insight-research-conference-2026-tickets-1981735621591?aff=oddtdtcreator

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National Institute for Health and Care Research @nihrresearch ·

31 Mar

We've launched lots of exciting funding and development opportunities in the last week!

Find them below 👇 or visit our website to see the full list of opportunities available: https://www.nihr.ac.uk/funding-opportunities

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NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

1 Apr

Want to find out more about what health and care research is and why we do it?
Then why not book onto this free webinar by Dr Joseph Lanario - Thursday 16 April | 6-7pm | Online
Booking link 👉https://bit.ly/4bNuFvO
@BirminghamBRC @NIHRresearch

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National Institute for Health and Care Research @nihrresearch ·

30 Mar

⏳ Final call: Applications are closing soon for Non-Executive Members of our new Council!

Help shape the strategic direction of health and care research in the UK. Apply by 10 April, 1pm ➡️https://www.nihr.ac.uk/honorary-and-specialty/nihr-council-non-executive-council-members

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NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

24 Mar

Congratulations to Professor Grant Stewart who has been newly appointed as an #NIHR Senior Investigator https://bit.ly/4bI0owR

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NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

21 Mar

Come and see us! We are at @CAST_Education (CAST) from 11am - 4pm for the @Cambridge_Fest Hands On Science Day!
👉 Learn more about research by taking part in our activities!
👉 full programme here: http://www.festival.cam.ac.uk
@NIHRresearch @CUH_NHS

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Data Science and Population Health

This Theme’s Focus

Theme Leads

Michael Inouye

Professor Angela Wood

The Data Science and Population Health theme will address two overarching research questions:

For more Information

Working with patients and the public

Podcast: Health Data Science Insights – Cambridge

Latest News

Data Science and Population Health Case Studies

Data Science and Population Health Publications

Contact Us

Useful Links