Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Publication: Science
Fotios Sampaziotis, Daniele Muraro, Olivia C. Tysoe, Stephen Sawiak, Timothy E. Beach, Edmund M. Godfrey, Sara S. Upponi, Teresa Brevini, Brandon T. Wesley, Jose Garcia-Bernardo, Krishnaa Mahbubani, Giovanni Canu,
Richard Gieseck, Natalie L. Berntsen, Victoria L. Mulcahy, Keziah Crick, Corrina Fear, Sharayne Robinson, Lisa Swift, Laure Gambardella, Johannes Bargehr, Daniel Ortmann, Stephanie E. Brown, Anna Osnato, Michael P. Murphy, Gareth Corbett, William T. H. Gelson, George F. Mells, Peter Humphreys, Susan E. Davies, Irum Amin,
Paul Gibbs, Sanjay Sinha, Sarah A. Teichmann, Andrew J. Butler, Teik Choon, Espen Melum, Christopher J. E. Watson, Kourosh Saeb-Parsy, Ludovic Vallier
18 February 2021
Summary:
Researchers in Cambridge have found a way to grow ‘mini bile ducts’ in a lab-setting to repair damaged livers. This new technique could potentially help treat patients whose own livers are not functioning correctly.
Using a recently developed ‘perfusion system’, they were able to transplant biliary cells grown in the lab known as cholangiocytes organoids into damaged human livers to repair them.
This is the first time that a procedure of this kind has been used on human donor organs. It could also increase the number of livers that are considered suitable for organ transplantation and ultimately save more lives.
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