Inflammation, infection and immunotherapeutics

Differences in granularity of control (LHS) and Nbeal2-deficient (RHS) neutrophils

Key areas of focus 

  • Investigation of adult primary immunodeficiency 
  • Immunotherapeutics (experimental medicine and clinical studies) and new approaches to autoimmunity
  • Translational targeting at the host- pathogen interface

The immune system is critical for defence against infection, and when dysfunctional can lead to autoimmune and inflammatory disease. It is increasingly recognised as an important mediator of many diseases previously not thought to be primarily immune-mediated, for example psychosis and dementia. Inflammation, infection and immunotherapeutics (III) will establish tools to investigate the immune system and health in its broadest sense, enabling all Research Themes to exploit this resource to benefit patients and the community.

The impact of the immune system on disease has recently been demonstrated to extend well beyond traditional immune-mediated diseases, and for this reason the III theme has been designated ‘’cross-cutting’’. This impact is hard to quantify but potentially enormous. For example, immunotherapy is creating a revolution in oncology, with many previously untreatable cancers responding to immune enhancement therapies.