Publications

Publication: Nature Communications

Robert C. Will, Thandavarayan Ramamurthy, Naresh Chand Sharma, Balaji Veeraraghavan, Lucky Sangal, Pradeep Haldar, Agila Kumari Pragasam, Karthick Vasudevan, Dhirendra Kumar, Bhabatosh Das, Eva Heinz, Vyacheslav Melnikov, Stephen Baker, Vartul Sangal, Gordon Dougan & Ankur Mutreja

8 March 2021


Summary

Diphtheria is a highly contagious infection that can affect the nose and throat, and sometimes the skin.

In a study published in Nature Communications,  an international team of researchers analysed the genomes of 61 bacteria isolated from patients and combining these with 441 publicly available genomes. They used this information to assess the presence of antimicrobial resistance (AMR) genes and assess toxin variation. Read the full story.

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Publication: Critical Care

Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Solderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott and  Andrew Conway Morris

11 January 2021


Summary:
A DNA test to identify secondary pneumonia in patients with severe COVID-19 has been created by Cambridge researchers. Bacteria samples need to be collected from patients and grown in a lab to identify them – this could take days. Now researchers have created a test which will detect the DNA of the bacteria within hours. Clinicians will then be able to start the right course of treatment a lot sooner. This new test is being rolled out at Cambridge University Hospitals.
Read the full news story.
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Publication: The Lancet Infectious Diseases

Luke W Meredith, William L Hamilton, Ben Warne, Charlotte J Houldcroft, Myra Hosmillo, Aminu S Jahun, Martin D Curran, Surendra Parmar, Laura G Caller, Sarah L Caddy, Fahad A Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Sally Forrest, Sushmita Sridhar, Michael P Weekes, Prof Stephen Baker, Nicholas Brown, Elinor Moore, Ashley Popay, Iain Roddick, Mark Reacher, Theodore Gouliouris, Prof Sharon J Peacock, Prof Gordon Dougan, M Estée Török, Prof Ian Goodfellow.

14 July 2020


Summary:

Cambridge researchers have shown how rapid genome sequencing of virus samples and enhanced testing of hospital staff can help to identify clusters of healthcare-associated COVID-19 infections. Read the full news article.

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Publication: Journal of Antimicrobial Chemotherapy

Pérez-Vázquez M, Sola Campoy PJ, Ortega A, Bautista V, Monzón S, Ruiz-Carrascoso G, Mingorance J, González-Barberá EM, Gimeno C, Aracil B, Sáez D, Lara N, Fernández S, González-López JJ, Campos J, Kingsley RA, Dougan G, Oteo-Iglesias J; Spanish NDM Study Group .  J Antimicrob Chemother.

3 September 2019

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Publication: Genome Biology

Ellington MJ, Heinz E, Wailan AM, Dorman MJ, de Goffau M, Cain AK, Henson SP, Gleadall N, Boinett CJ, Dougan G, Brown NM, Woodford N, Parkhill J, Török ME, Peacock SJ, Thomson NR.

2 September 2019

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Publication: EMBO Molecular Medicine

Blohmke CJ, Muller J, Gibani MM, Dobinson H, Shrestha S, Perinparajah S, Jin C, Hughes H, Blackwell L, Dongol S, Karkey A, Schreiber F, Pickard D, Basnyat B, Dougan G, Baker S, Pollard AJ, Darton TC.

30 August 2019

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Publication: Nature Genetics

Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD.

12 August 2019

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Publication: Clinical Infectious Diseases

Dyson ZA, Klemm EJ, Palmer S, Dougan G.

7 March 2019

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Publication: Scientific Reports

Heinz E, Ejaz H, Bartholdson Scott J, Wang N, Gujaran S, Pickard D, et al.  NDM-1.

20 February 2019

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Publication: Cell and Molecular Gastroenterology and Hepatology

Kraiczy J, Ross ADB, Forbester JL, Dougan G, Vallier L, Zilbauer M.

23 October 2018

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Publication: Proceedings of the National Academy of Sciences USA

Klemm EJ, Wong VK, Dougan G.

18 December 2018

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Publication: Nature Communications

Park SE, Pham DT, Boinett C, Wong VK, Pak GD, Panzner U, et al.

30 November 2018

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Publication: PLoS Neglected Tropical Diseases

Britto CD, Wong VK, Dougan G, Pollard AJ.

11 October 2018

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Publication: American Society for Microbiology

Klemm EJ, Shakoor S, Page AJ, Qamar FN, Judge K, Saeed DK, Wong VK, Dallman TJ, Nair S, Baker S, Shaheen G, Qureshi S, Yousafzai MT, Saleem MK, Hasan Z, Dougan G, Hasan R

20 February 2018

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Publication: PNAS

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.

14 September 2018

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Publication: American Society for Microbiology

Mather AE, Phuong TLT, Gao Y, Clare S, Mukhopadhyay S, Goulding DA, Hoang NTD, Tuyen HT, Lan NPH, Thompson CN, Trang NHT, Carrique-Mas J, Tue NT, Campbell JI, Rabaa MA, Thanh DP, Harcourt K, Hoa NT, Trung NV, Schultsz C, Perron GG, Coia JE, Brown DJ, Okoro C, Parkhill J, Thomson NR, Chau NVV, Thwaites GE, Maskell DJ, Dougan G, Kenney LJ, Baker S.

4 September 2018

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Publication: The Journal of Hospital Infection

Wilson HJ, Khokhar F, Enoch DA, Brown NM, Ahluwalia J, Dougan G, et al.

2 July 2018

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Publication: Microbial Genomics

Houldcroft CJ, Beale MA, Sayeed MA, Qadri F, Dougan G, Mutreja A.

24 September 2018

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Publication: Global Health, Epidemiology and Genomics

Allcock S, Young EH, Holmes M, Gurdasani D, Dougan G, Sandhu MS, Solomon L, Török ME.

10 May 2017

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Publication:

Klemm EJ, Gkrania-Klotsas E, Hadfield J, Forbester JL, Harris SR, Hale C, Heath JN, Wileman T, Clare S, Kane L, Goulding D, Otto TD, Kay S, Doffinger R, Cooke FJ, Carmichael A, Lever AM, Parkhill J, MacLennan CA, Kumararatne D, Dougan G*, Kingsley R.A.* (*equal authors)

25 January 2016

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Publication: Nat Genet

Wong VK, Baker S, Pickard DJ, Parkhill J, Page AJ, Feasey NA, Kingsley RA, Thomson NR, Keane JA, Weill FX, Edwards DJ, Hawkey J, Harris SR, Mather AE, Cain AK, Hadfield J, Hart PJ, Thieu NT, Klemm EJ, Glinos DA, Breiman RF, Watson CH, Kariuki S, Gordon MA, Heyderman RS, Okoro C, Jacobs J, Lunguya O, Edmunds WJ, Msefula C, Chabalgoity JA, Kama M, Jenkins K, Dutta S, Marks F, Campos J, Thompson C, Obaro S, MacLennan CA, Dolecek C, Keddy KH, Smith AM, Parry CM, Karkey A, Mulholland EK, Campbell JI, Dongol S, Basnyat B, Dufour M, Bandaranayake D, Naseri TT, Singh SP, Hatta M, Newton P, Onsare RS, Isaia L, Dance D, Davong V, Thwaites G, Wijedoru L, Crump JA, De Pinna E, Nair S, Nilles EJ, Thanh DP, Turner P, Soeng S, Valcanis M, Powling J, Dimovski K, Hogg G, Farrar J, Holt KE, Dougan G.

11 May 2015

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Publication: Nat Genet

von Mentzer A, Connor TR, Wieler LH, Semmler T, Iguchi A, Thomson NR, Rasko DA, Joffre E, Corander J, Pickard D, Wiklund G, Svennerholm AM, Sjöling A, Dougan G. Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution.

10 November 2014

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Publication: Nat Genet

He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, Connor TR, Harris SR, Fairley D, Bamford KB, D’Arc S, Brazier J, Brown D, Coia JE, Douce G, Gerding D, Kim HJ, Koh TH, Kato H, Senoh M, Louie T, Michell S, Butt E, Peacock SJ, Brown NM, Riley T, Songer G, Wilcox M, Pirmohamed M, Kuijper E, Hawkey P, Wren BW, Dougan G, Parkhill J, Lawley TD

9 December 2012

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Publication: Nat Genet

Okoro CK, Kingsley RA, Connor TR, Harris SR, Parry CM, Al-Mashhadani MN, Kariuki S, Msefula CL, Gordon MA, de Pinna E, Wain J, Heyderman RS, Obaro S, Alonso PL, Mandomando I, Maclennan CA, Tapia MD, Levine MM, Tennant SM, Parkhill J, Dougan G.

30 September 2012

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Publication: Nature

Mutreja A, Kim DW, Thomson NR, Connor TR, Lee JH, Kariuki S, Croucher NJ, Choi SY, Harris SR, Lebens M, Niyogi SK, Kim EJ, Ramamurthy T, Chun J, Wood JL, Clemens JD, Czerkinsky C, Nair GB, Holmgren J, Parkhill J, Dougan G. Evidence for several waves of global transmission in the seventh cholera pandemic.

24 August 2011

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Publication: Nature Genetics

Holt K.E., Parkhill J., Mazzoni C.J., Roumagnac P., Weill F-X., Goodhead I., Rance R., Baker S., Maskell D., Wain J., Dolecek C., Achtman M. and Dougan.

27 July 2008

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Publication: Nature

Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larson T.S., Leather S., Moule S., O’Goara P., Parry C., Quail M., Rutherford K., Simmonds M., Skelton J., Stevens K., Whitehead S. and B.G Barrell

25 October 2001

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