Publications

The latest list of publications from the Cambridge Biomedical Research Centre with a brief summary. 

Publication: Genomic and Precision Medicine

Paige E, Clement M, Lareyre F, Sweeting M, Raffort J, Grenier C, et al.

18 January 2019

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Publication: Nature Communications

Emdin CA, Khera AV, Chaffin M, Klarin D, Natarajan P, Aragam K, et al.

24 April 2018

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Publication: International Journal of Obesity

White T, Westgate K, Hollidge S, Venables M, Olivier P, Wareham N,

2 April 2019

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Publication: Nature Communications

Yao C, Chen G, Song C, Keefe J, Mendelson M, Huan T, et al. .

15 August 2018

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Publication: The Journal of Clinical Endocrinology & Metabolism

Zheng JS, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I, Gundersen TE, et al.

9 November 2018

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Publication: International Journal of Behavioral Nutrition and Physical Activity

Hajna S, White T, Brage S, van Sluijs EMF, Westgate K, Jones AP, et al.

27 November 2018

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Publication: Nutrients

Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A.

3 November 2018

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Publication: Current Gerontology and Geriatrics Research

Hartley P, Keevil VL, Westgate K, White T, Brage S, Romero-Ortuno R, et al. Curr Gerontol Geriatr Res.

18 October 2018

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Publication: Journal of Child Psychology and Psychiatry

Meiser-Stedman R, McKinnon A, Dixon C, Boyle A, Smith P, & Dalgleish T

25 March 2019

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Publication: Frontiers in Immunology

Jacqueline H. Y. Siu, Veena Surendrakumar, James A. Richards and Gavin J. Pettigrew

5 November 2018


Summary:

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; and as self-restricted processed alloantigen via the indirect pathway. Direct pathway responses are viewed as strong but short-lived and hence responsible for acute rejection, whereas indirect pathway responses are typically thought to be much longer lasting and mediate the progression of chronic rejection. However, this is based on surprisingly scant experimental evidence, and the recent demonstration that MHC alloantigen can be re-presented intact on recipient dendritic cells—the semi-direct pathway—suggests that the conventional view may be an oversimplification.

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