Publications

The latest list of publications from the Cambridge Biomedical Research Centre with a brief summary. 

Publication: Nature Communications

Emdin CA, Khera AV, Chaffin M, Klarin D, Natarajan P, Aragam K, et al.

2018 Apr 24;9(1):1613.

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Publication: International Journal of Obesity

White T, Westgate K, Hollidge S, Venables M, Olivier P, Wareham N,

2019 Apr 2;

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Publication: Nature Communications

Yao C, Chen G, Song C, Keefe J, Mendelson M, Huan T, et al. .

2018 Aug 15;9(1):3268.

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Publication: The Journal of Clinical Endocrinology & Metabolism

Zheng JS, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I, Gundersen TE, et al.

2018 Nov 9;

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Publication: International Journal of Behavioral Nutrition and Physical Activity

Hajna S, White T, Brage S, van Sluijs EMF, Westgate K, Jones AP, et al.

2018 Nov 27;15(1):122

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Publication: Nutrients

Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A.

2018 Nov 3;10(11)

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Publication: Current Gerontology and Geriatrics Research

Hartley P, Keevil VL, Westgate K, White T, Brage S, Romero-Ortuno R, et al. Curr Gerontol Geriatr Res.

2018 Oct 18;2018:3280240

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Publication: Journal of Child Psychology and Psychiatry

Meiser-Stedman R, McKinnon A, Dixon C, Boyle A, Smith P, & Dalgleish T

(2019)

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Publication: Journal of Autism and Developmental Disorders

Hull L, Mandy W, Lai MC, Baron-Cohen S, Allison C, Smith P, Petrides KV

2019 Mar 15;49(3):819-33.

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Publication: Frontiers in Immunology

Jacqueline H. Y. Siu, Veena Surendrakumar, James A. Richards and Gavin J. Pettigrew

5 November 2018


Summary:

Transplantation is unusual in that T cells can recognize alloantigen by at least two distinct pathways: as intact MHC alloantigen on the surface of donor cells via the direct pathway; and as self-restricted processed alloantigen via the indirect pathway. Direct pathway responses are viewed as strong but short-lived and hence responsible for acute rejection, whereas indirect pathway responses are typically thought to be much longer lasting and mediate the progression of chronic rejection. However, this is based on surprisingly scant experimental evidence, and the recent demonstration that MHC alloantigen can be re-presented intact on recipient dendritic cells—the semi-direct pathway—suggests that the conventional view may be an oversimplification.

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