The latest list of publications from the Cambridge Biomedical Research Centre with a brief summary.
Publication: The Lancet
Gemma D Banham, MRCP(UK), Shaun M Flint, FRACP, Nicholas Torpey, FRCP, Paul A Lyons, PhD, Don N Shanahan, MSc, Adele Gibson, BSc, Prof Christopher J E Watson, FRCS, Ann-Marie O’Sullivan, MRes, Joseph A Chadwick, Katie E Foster, PhD, Rachel B Jones, FRCP, Luke R Devey, MRCSEd, Anna Richards, MRCP(UK), Prof Lars-Peter Erwig, MD, Prof Caroline O Savage,FMedSci, Prof Kenneth G C Smith, FMedSci, Robert B Henderson, PhD, Menna R Clatworthy, FRCP†,
Transplantation is the best form of treatment for most patients with end-stage renal failure, but long-term graft survival is limited by the development of antibodies against the graft. There is therefore a major unmet need to find immunosuppressants that target humoral alloimmunity.
Researchers investigated the use of Belimumab, a monoclonal antibody that binds the B cell pro-survival cytokine BAFF, in kidney transplant recipients.
The study found that the use of belimumab was not associated with any excess risk of infection, and led to a reduction in antibody-producing plasmablasts, activated memory B cells, new IgG antibody formation and in non-HLA IgG antibodies associated with poor graft outcomes. Remarkably, belimumab treatment spared regulatory B cells – a cell type associated with transplant tolerance, with an increase in IL10-producing B cells observed.View publication
Linda M. O’Keeffe, PhD; Anna Ramond, DPharm; Clare Oliver-Williams, PhD; Peter Willeit, MD; Ellie Paige, PhD; Patrick Trotter, MBChB; Jonathan Evans, MBChB; Jonas Wadström, MD; Michael Nicholson, MD; Dave Collett, PhD; Emanuele Di Angelantonio, MD
Living kidney donors are not at increased risk for some health outcomes previously of concern, but do seem at risk for worse blood pressure and kidney function than nondonors. In addition, female donors seem to be at increased risk for preeclampsia.
A team lead by researchers reviewed 52 published studies comprising more than 100,000 living kidney donors and more than 110,000 nondonors to assess the mid- and long-term health risks associated with living kidney donation in adults.
The data showed that kidney donors had higher diastolic blood pressure, poorer renal function, and higher risk for ESRD than nondonors. Female donors had an almost two-fold higher risk than nondonors for pregnancy-related complications, such as preeclampsia.
There was no evidence that living kidney donors had higher risk for mortality, cardiovascular disease, or type 2 diabetes, or reduced quality of life.View publication
Publication: European Journal of Neurosciences
Greenland JC, Williams-Gray CH, Barker RA.
2019 Feb;49(3):328-338View publication
Sun YQ, Burgess S, Staley JR, Wood AM, Bell S, Kaptoge SK, et al.
2019 Mar 26;364:l1042.View publication
Publication: American Journal of Transplantation
Ines G. Harper, Olivera Gjorgjimajkoska, Jacqueline H. Y. Siu, Jasvir Parmar, Arend Mulder, Frans H. J. Claas, Sarah A. Hosgood, Michael L. Nicholson, Reza Motallebzadeh, Gavin J. Pettigrew
12 December 2018
Tissue resident lymphocytes are present within many organs, and are presumably transferred at transplantation, but their impact on host immunity is unclear. Here, we examine whether transferred donor natural regulatory CD4 T cells (nT‐regs) inhibit host alloimmunity and prolong allograft survival.View publication
Publication: European Respiratory Journal
Sofianopoulou E, Kaptoge S, Graf S, Hadinnapola C, Treacy CM, Church C, et al.
2019 Mar 28.View publication
Publication: Circulation: Genomic and Precision Medicine.
Larsson SC, Allara E, Mason AM, Michaelsson K, Burgess S.
2019 Mar;12(3):e002468.View publication
Publication: The New England Journal of Medicine
Ference BA, Ray KK, Catapano AL, Ference TB, Burgess S, Neff DR, et al.
N Engl J Med. 2019 Mar 14;380(11):1033-1042.View publication
Publication: American Heart Journal
Mukhtar O, Cheriyan J, Cockcroft JR, Collier D, Coulson JM, Dasgupta I, et al.
2018 Oct;204:102-108View publication
Luo S, Au Yeung SL, Zhao JV, Burgess S, Schooling CM.
2019 Mar 6;364:l476.View publication
Publication: Nature Communications
Wittemans LBL, Lotta LA, Oliver-Williams C, Stewart ID, Surendran P, Karthikeyan S, et al.
2019 Mar 5;10(1):1060View publication
Publication: Genomic and Precision Medicine
Paige E, Clement M, Lareyre F, Sweeting M, Raffort J, Grenier C, et al.
2019 Feb;12(2):e002413.View publication