The latest list of publications from the Cambridge Biomedical Research Centre with a brief summary. 

If you are publishing research which has had funding and / or support from the NIHR Cambridge Biomedical Research Centre, please complete the attached form

Publication: Genome Biology

Ellington MJ, Heinz E, Wailan AM, Dorman MJ, de Goffau M, Cain AK, Henson SP, Gleadall N, Boinett CJ, Dougan G, Brown NM, Woodford N, Parkhill J, Török ME, Peacock SJ, Thomson NR.

2 September 2019

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Publication: The Lancet Global Health

Stephen Kaptoge, Lisa Pennells, Dirk De Bacquer, Marie Therese Cooney, Maryam Kavousi, Oyere Onuma, Mark Woodward, Goodarz Danaei, Gregory Roth, Shanthi Mendis, Ian Graham, Cherian Varghese, Majid Ezzati, Rod Jackson, John Danesh & Emanuele Di Angelantonio

1 September 2019


Cambridge-led researchers have updated World Health Organisation (WHO) cardiovascular disease (CVD) risk prediction charts to aid efforts to reduce the burden of CVD, one of the most common non-communicable diseases world-wide and responsible for an estimated 17.8 million deaths in 2017.

The research was funded by the National Institute for Health Research Cambridge Biomedical Research Centre, WHO, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence and UK Medical Research Council.

The revised risk models will help particularly middle- to low-income countries in their efforts to prevent and control CVD. Full story here

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Publication: EMBO Molecular Medicine

Blohmke CJ, Muller J, Gibani MM, Dobinson H, Shrestha S, Perinparajah S, Jin C, Hughes H, Blackwell L, Dongol S, Karkey A, Schreiber F, Pickard D, Basnyat B, Dougan G, Baker S, Pollard AJ, Darton TC.

30 August 2019

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Publication: Nature Genetics

Geoff Macintyre, Teodora E. Goranova, Dilrini De Silva, Darren Ennis, Anna M. Piskorz, Matthew Eldridge, Daoud Sie, Liz-Anne Lewsley, Aishah Hanif, Cheryl Wilson, Suzanne Dowson, Rosalind M. Glasspool, Michelle Lockley, Elly Brockbank, Ana Montes, Axel Walther, Sudha Sundar, Richard Edmondson, Geoff D. Hall, Andrew Clamp, Charlie Gourley, Marcia Hall, Christina Fotopoulou, Hani Gabra, James Paul, Anna Supernat, David Millan, Aoisha Hoyle, Gareth Bryson, Craig Nourse, Laura Mincarelli, Luis Navarro Sanchez, Bauke Ylstra, Mercedes Jimenez-Linan, Luiza Moore, Oliver Hofmann, Florian Markowetz, Iain A. McNeish and James D. Brenton

13 August 2018


Researchers have found distinct patterns of DNA rearrangement that are linked to patient outcomes.

In this study of ovarian cancer samples from over 500 women, the research team harnessed big data processing techniques to look for broad patterns in the genetic readouts from ovarian cancer cells.

Rather than focusing on the detail of each individual mistake in the DNA, they designed powerful computer algorithms to scan the genetic data, finding seven distinct patterns.

They showed that each pattern, or “signature”, represented a different mechanism of DNA mutation. Taken together, these signatures were able to make sense of the chaos seen in ovarian cancer genomes. Read the full story here

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Publication: Nature Genetics

Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD.

12 August 2019

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Publication: Nature Biotechnology

Johannes Bargehr, Lay Ping Ong, Maria Colzani, Hongorzul Davaapil, Peter Hofsteen, Shiv Bhandari, Laure Gambardella, Nicolas Le Novère, Dharini Iyer, Fotios Sampaziotis, Florian Weinberger, Alessandro Bertero, Andrea Leonard, William G. Bernard, Amy Martinson, Nichola Figg, Michael Regnier, Martin R. Bennett, Charles E. Murry & Sanjay Sinha

2 August 2019


Transplanting an area of damaged tissue with a combination of both heart and muscle cells and supportive cells taken from the outer layer of the heart wall, may be able to help the organs recover from the damage caused by a heart attack. Part funded by the BHF and NIHR and supported by the NIHR Cambridge BRC, researchers have used supportive epicardial cells developed from human stem cells to help transplanted heart cells live longer. Full story here

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Publication: Nature

Marcus C. de Goffau, Susanne Lager, Ulla Sovio, Francesca Gaccioli, Emma Cook, Sharon J. Peacock, Julian Parkhill, D. Stephen Charnock-Jones & Gordon C. S. Smith
31 July 2019

This paper from the Department of Obstetrics and Gynaecology at the University of Cambridge presents three key messages: (1) the placenta does not have a microbiome; (2) bacterial infection of the placenta is not a common cause of adverse pregnancy outcome; and (3) the placenta is however a potential site of perinatal acquisition of Streptococcus agalactiae, a major cause of neonatal sepsis.
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Publication: Nature Medicine

Felipe A. Vieira Braga, Gozde Kar, Marijn Berg, Orestes A. Carpaij, Krzysztof Polanski, Lukas M. Simon, Sharon Brouwer, Tomás Gomes, Laura Hesse, Jian Jiang, Eirini S. Fasouli, Mirjana Efremova, Roser Vento-Tormo, Carlos Talavera-López, Marnix R. Jonker, Karen Affleck, Subarna Palit, Paulina M. Strzelecka, Helen V. Firth, Krishnaa T. Mahbubani, Ana Cvejic, Kerstin B. Meyer, Kourosh Saeb-Parsy, Marjan Luinge, Corry-Anke Brandsma, Wim Timens, Ilias Angelidis, Maximilian Strunz, Gerard H. Koppelman, Antoon J. van Oosterhout, Herbert B. Schiller, Fabian J. Theis, Maarten van den Berge, Martijn C. Nawijn, Sarah A. Teichmann

17 June 2019



This research carried out a survey of structural and immune cells in the airways of healthy and asthmatic lungs and identified a novel set of T cells resident in asmatic airways. There is altered communication between immune and structural cells in asthmatic airways and these changes underlie the inflammation in these airways.

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Publication: Pediatric Nephrology

Jack L. Martin, Anja V. Gruszczyk, Timothy E. Beach, Michael P. Murphy, Kourosh Saeb-Parsy 

2 June 2018


Acute kidney injury (AKI) is a major problem in critically unwell children, including ischaemic reperfusion (IR) injury involving mitochondria. This research proposes a variety of novel therapeutic targets as potential treaments of AKI.

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Publication: Brain

David Howett, Andrea Castegnaro, Katarzyna Krzywicka, Johanna Hagman, Deepti Marchment, Richard Henson, Miguel Rio, John A King, Neil Burgess, Dennis Chan

May 19


This research showed that a virtual reality test of spatial navigation was more effective at identifying patients with mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) than gold standard tests of memory and thinking currently used in clinic and research studies. More here

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Publication: Journal of Autoimmunity

M. Saeed Qureshi, Jawaher Alsughayyir, Manu Chhabra, Jason M. Ali, Martin J. Goddard, Christopher A. Devine, Thomas M. Conlon, Michelle A. Linterman, Reza Motallebzadeh, Gavin J.Pettigrew

7 December 2018


The development of humoral autoimmunity following organ transplantation is increasingly recognised, but of uncertain significance. We examine whether autoimmunity contributes independently to allograft rejection.

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Publication: Neuroimage

Grist JT, McLean MA, Riemer F, Schulte RF, Deen SS, Zaccagna F, et al.

1 April 2019

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