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The latest list of publications from the Cambridge Biomedical Research Centre with a brief summary.

If you are publishing research which has had funding and / or support from the NIHR Cambridge Biomedical Research Centre, please complete the attached form.

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

Publication: PLoS Med

Lotta L.A, Scott R.A, Sharp S.J, Burgess, S. Luan, J. Tillin, T, et al.

29 November 2016

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Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis

Publication: JAMA

Lotta L. A, Sharp S. J, Burgess S, Perry J. R, Stewart, I. D, et al.

4 October 2016

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Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials

Publication: PLoS Medicine

Imamura F, Micha R, Wu, J. H, de Oliveira Otto, M. C, Otite, F. O, et al.

19 July 2016

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Genome-wide associations for birth weight and correlations with adult disease

Publication: Nature

Horikoshi M, Beaumont R. N, Day F. R, Warrington N. M., Kooijman M. N, et al.

13 October 2016

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The genetic architecture of type 2 diabetes

Publication: Nature

Fuchsberger C, Flannick J, Teslovich T. M, Mahajan A, Agarwala, V, et al.

11 July 2016

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Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study

Publication: PLoS Medicine

Forouhi N. G, Imamura F, Sharp, S. J, Koulman A, Schulze, M. B, et al.

19 July 2016

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Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women

Publication: Lancet

Ekelund U, Steene-Johannessen J, Brown W. J, Fagerland M. W, Owen N, et al.

24 September 2016

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Physical and neurobehavioral determinants of reproductive onset and success

Publication: Nature Genetics

Day F. R, Helgason H, Chasman D. I, Rose L. M, Loh P. R, et al.

June 2016

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Dietary Diversity, Diet Cost, and Incidence of Type 2 Diabetes in the United Kingdom: A Prospective Cohort Study

Publication: PLoS Medicine

Conklin A. I, Monsivais P, Khaw K. T, Wareham N. J, and Forouhi N. G.

19 July 2016

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Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource

Publication: Genome Research

Keogh MJ, Wei W, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie C, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF

21 December 2016

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The RESCUEicp Trial Collaborators. Trial of decompressive craniectomy for traumatic intracranial hypertension

Publication: N Engl J Med

Hutchinson PJ, Kolias AG, Timofeev IS, Corteen E, Czosnyka M, Timothy J, Anderson I, Bulters DO, Belli A, Eynon CA, Wadley J, Mendelow AD, Mitchell PM, Wilson MH, Critchley G, Sahuquillo J, Unterberg A, Servadei F, Teasdale GM, Pickard JD, Menon DK, Murray GD, Kirkpatrick PJ

22 September 2016

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Recombinant human interleukin-1 receptor antagonist promotes M1 microglia biased cytokines and chemokines following human traumatic brain injury

Publication: J Cereb Blood Flow Metab

Helmy A, Guilfoyle MR, Carpenter KL, Pickard JD, Menon DK, Hutchinson PJ

1 December 2015

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