Publications

The latest list of publications from the Cambridge Biomedical Research Centre with a brief summary. 

Publication: BMJ

Loes CA Rutten-Jacobs, Susanna C Larsson,, Rainer Malik,, Kristiina Rannikmäe, MEGASTROKE consortium, International Stroke Genetics Consortium, Cathie L Sudlow, Martin Dichgans, Hugh S Markus, professor2, Matthew Traylor


Summary:

Researchers investigated whether a genetic risk score for stroke is associated with actual (“incident”) stroke in a large population of British adults.

They developed a genetic risk score based on 90 gene variants known to be associated with stroke from 306,473 white men and women in the UK Biobank – a database of biological information from half a million British adults.

Participants were aged between 40 and 73 years and had no history of stroke or heart attack. Adherence to a healthy lifestyle was based on four factors: non-smoker, diet rich in fruit, vegetables and fish, not overweight or obese (body mass index less than 30), and regular physical exercise.

A high genetic risk combined with an unfavourable lifestyle profile was associated with a more than twofold increased risk of stroke compared with a low genetic risk and a favourable lifestyle. Full story here

View publication

Publication: PLoS Neglected Tropical Diseases

Britto CD, Wong VK, Dougan G, Pollard AJ.

2018 Oct;12(10):e0006779

View publication

Publication: American Society for Microbiology

Klemm EJ, Shakoor S, Page AJ, Qamar FN, Judge K, Saeed DK, Wong VK, Dallman TJ, Nair S, Baker S, Shaheen G, Qureshi S, Yousafzai MT, Saleem MK, Hasan Z, Dougan G, Hasan R

2018 9. pii: e00105-18.

View publication

Publication: PNAS

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.

2018 115:10118-10123.

View publication

Publication: Clinical Gastroenterology Hepatology

Hegade VS, Mells GF, Fisher H, Kendrick S, DiBello J, Gilchrist K, et al.

2018 Dec 14;

View publication

Publication: American Society for Microbiology

Mather AE, Phuong TLT, Gao Y, Clare S, Mukhopadhyay S, Goulding DA, Hoang NTD, Tuyen HT, Lan NPH, Thompson CN, Trang NHT, Carrique-Mas J, Tue NT, Campbell JI, Rabaa MA, Thanh DP, Harcourt K, Hoa NT, Trung NV, Schultsz C, Perron GG, Coia JE, Brown DJ, Okoro C, Parkhill J, Thomson NR, Chau NVV, Thwaites GE, Maskell DJ, Dougan G, Kenney LJ, Baker S.

2018 Sep 4;9(5). pii: e01056-18. doi: 10.1128/mBio.01056-18.

 

View publication

Publication: Australian & New Zealand Journal of Psychiatry

Chamberlain SR, Tiego J, Fontenelle LF, Hook R, Parkes L, Segrave R, Hauser TU, Dolan RJ, Goodyer IM, Bullmore E, Grant JE, Yucel M.

2019

View publication

Publication: The Journal of Hospital Infection

Wilson HJ, Khokhar F, Enoch DA, Brown NM, Ahluwalia J, Dougan G, et al.

2018 Sep;100(1):35-39

View publication

Publication: Brain

Smets I, Fiddes B, Garcia-Perez JE, He D, Mallants K, Liao W, et al.

2018 Mar 1;141(3):786-79

View publication

Publication: Journal of Alzheimer's Disease

Raha-Chowdhury R, Henderson JW, Raha AA, Vuono R, Bickerton A, Jones E, Fincham R, Allinson K, Holland A, Zaman SH.

2019 Mar 1(Preprint):1-9.

View publication

Publication: Clinical Endicrinology

Wong MY, Andrews KA, Challis BG, Park SM, Acerini CL, Maher ER, et al.

2018 Dec 27;

View publication

Publication: Mit Press Journals

Anna O Ermakova, Nimrod Gileadi, Franziska Knolle, Azucena Justicia Diaz, Rachel Anderson, Paul C Fletcher, Michael Moutoussis, Graham K Murray.

doi/10.1162/cpsy_a_00020

View publication
Discover more

If you would like more information about the NIHR Cambridge BRC, please contact us.