Nutrition, Obesity, Metabolism and Endocrinology

This Theme’s Focus

Nutrition and prevention of metabolic diseases
Improved diagnosis and treatment of obesity and diabetes
Development of new technologies to diagnose hormonal conditions and tumours

Our research aims to improve the lives and health of people with obesity, diabetes and related metabolic and endocrine diseases. We use a number of approaches including genetics and imaging to determine why these conditions occur and to improve prevention, early diagnosis and develop safe and effective treatments.

Theme Leads

Professor Sadaf Farooqi

Professor of Metabolism and Medicine at the University of Cambridge and an Honorary Consultant in Diabetes and Endocrinology at Addenbrooke’s Hospital, Cambridge.
Email: isf20@medschl.cam.ac.uk

Professor Nita Forouhi

Director of Organisational Affairs for the School of Clinical Medicine and NIHR Senior Investigator
Email: nita.forouhi@mrc-epid.cam.ac.uk

Meet our researchers

Our research has six broad sub-themes with the following aims:

Nutrition, Physical Activity, Metabolic Disease and Prevention

We study population-based cohorts using genetics and other approaches to develop precision prevention for Type 2 Diabetes.

In this aim, we will also develop digital tools to assess diet and activity levels which can be deployed to deliver personalised interventions to improve the health of people with obesity, diabetes and related conditions.

Severe Obesity

We will deliver stratified weight-loss therapy to help people with severe obesity.

We will work to assess and improve the stigma faced by children with severe obesity.

Type 1 and Type 2 Diabetes

We will assess how the artificial pancreas (a device which calculates how much insulin people with diabetes need to control their blood sugar) can help people with complex nutritional needs.

Fatty liver disease and Severe Insulin Resistance

We will work to identify biomarkers which predict who may develop severe forms of liver disease and explore the use of new treatments for people with conditions which cause too much fat to go into the liver (called lipodystrophy).

Osteoporosis, Endocrine disorders and Endocrine tumours

We will use state-of-the-art imaging technologies to detect new endocrine tumours and osteoporosis at an early stage so that people can receive targeted therapies.

We will develop mechanism-based therapies for patients with genetic thyroid disorders.

Endocrine signals and biomarkers of systemic disease

We will develop new technologies that can be used to investigate how hormones cause a range of conditions such as chemotherapy-induced nausea and hyperemesis gravidarum in pregnancy.

Latest News

Cambridge Professor Stephen O’Rahilly honoured with the Berthold Medal for work in Endocrinology

March 26, 2025

Professor Krishna Chatterjee has been awarded the Gerald D. Aurbach Award for Outstanding Translational Research from the Endocrine Society.

Photo of Krish, a man with short hair and a moustache, standing in front of some greenery

Cambridge professor receives top award for outstanding research in endocrinology

August 22, 2024

Professor Krishna Chatterjee has been awarded the Gerald D. Aurbach Award for Outstanding Translational Research from the Endocrine Society.

Researcher awarded prestigious Academy of Medical Sciences Fellowship

May 22, 2024

Congratulations to Professor Nita Forouhi, NIHR Senior Investigator and co-theme lead for Nutrition, Obesity, Metabolism and Endocrinology, who has been elected as a fellow of the Academy of Medical Sciences.

Close up image of pregnant woman - Redgular from Pixabay

Cambridge-led study discovers cause of pregnancy sickness – and potential treatment

December 13, 2023

A study supported by NIHR Cambridge BRC has shown why many women experience nausea and vomiting during pregnancy – and why some women become so sick they need to be admitted to hospital.

Prestigious laureate award for Theme Lead Prof Farooqi

August 22, 2023

Our Nutrition, Obesity, Metabolism and Endocrinology Theme Lead…

Obesity accelerates loss of COVID-19 vaccination immunity, study finds

May 12, 2023

A new study has found the protection offered by COVID-19 vaccination declines more rapidly in people with severe obesity than in those with normal weight. It suggests that people with obesity are likely to need more frequent booster doses to maintain their immunity.

NICE recommends Cambridge-developed ‘artificial pancreas’ for use on NHS for management of type 1 diabetes

January 17, 2023

The artificial pancreas for type 1 diabetes – which was developed…

Artificial pancreas app, insulin pump and glucose monitor

Artificial pancreas successfully trialled for use by type 2 diabetes patients

January 12, 2023

Cambridge researchers have successfully trialled an artificial pancreas for people living with type 2 diabetes.

Professor Krishna Chatterjee awarded a CBE

January 5, 2023

Professor Krishna Chatterjee, director of NIHR Cambridge Clinical Research Facility, has been awarded a CBE in the King's New Year Honours.

Cambridge researchers awarded Fellow status

May 11, 2022

Eight Cambridge researchers are elected as Fellows of the Academy of Medical Sciences.

Sofia and Sam with the artificial pancreas

Artificial pancreas proves ‘life-changing’ for very young children with type 1 diabetes and their families

January 20, 2022

An artificial pancreas developed by Cambridge researchers and supported by the NIHR Cambridge BRC, has found it is both safe to use and more effective at managing blood sugar levels in young children than current technology.

Children holding hands - cherylholt from Pixabay

New research shows how our brain uses nutritional state to control growth and age at puberty

November 4, 2021

Rearchers have discovered how a receptor in the brain detects the nutritional state of the body and regulates the timing of puberty and rate of growth in children.

Previous Next

Nutrition, Obesity, Metabolism and Endocrinology Case Studies

Artificial pancreas is helping protect very young children with type 1 diabetes

October 16, 2024

Researchers compared the performance of the artificial pancreas,…

Brain receptor uses nutritional state to control growth and age at puberty

October 16, 2024

Researchers have discovered how a receptor in the brain,…

Artificial pancreas trialled for outpatients with type 2 diabetes for first time

October 16, 2024

An artificial pancreas could soon help people living with…

Person wearing some jeans that are too big around the waist

A single gene could be the reason why some of us carry an extra 30 pounds of fat

October 16, 2024

New research has found that one in every 340 people might…

Measuring stomach - PublicDomainPictures from Pixabay

How do our genes affect our weight

October 16, 2024

Researchers have known for some time that body weight is…

Graphic of a persons stomach with 3 labels numbered 1, 2 and 3

Artificial pancreas an international success

October 16, 2024

Poor management of blood sugar levels for people with diabetes…

Previous Next

Nutrition, Obesity, Metabolism and Endocrinology Publications

Leptin-mediated changes in the human metabolome

June 4, 2020

Quantitative 3D imaging parameters improve prediction of hip osteoarthritis outcome

March 5, 2020

GDF15 mediates the effects of metformin on body weight and energy balance

December 25, 2019

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

April 18, 2019

The lysosomal disease caused by mutant VPS33A

April 10, 2019

The NIHR Cambridge BRC is part of the NIHR and hosted by Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge. We are at the heart of the Cambridge Biomedical Campus, Europe’s largest health research area.

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8 Jan

The Cambridge-led IVORY trial has shown that targeting the immune system, by giving a low-dose of aldesleukin, could prevent future heart attacks by nearly 8%.

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6 Jan

📣 The Milner Consortium Call returns with its sixth call for research proposals. Academic researchers – join our Q&A webinar to learn more and ask questions about the Call!

🗓️ 22 Jan ⏰ 10am 📍 Online

🔗 Register: https://ow.ly/5PMb50XCIuF

🔗 More info: http://www.milner.cam.ac.uk/consortiumcall/

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5 Jan

👉 Want to help shape a future trial focused on preventing falls in older people?
👉 Are you an older adult and/or family member/carer? 👉 Free on Wed 21st Jan 2026 at 13.30 for an online group?
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31 Dec

🎉Wishing everyone a very Happy New Year!🎉
Thinking of making a #NewYearsResolution?
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Live in the #EastOfEngland?
Then why not join our Patient & Public Involvement Panel >> https://bit.ly/3LlRX1c
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24 Dec

Merry Christmas and a happy #NewYear from the #NIHR #Cambridge BRC!!
#Thankyou to all our amazing staff, everyone who has supported us and all those who took part in #research this year!
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22 Dec

🥳 As 2025 draws to a close, we’ve put together a snapshot of some of our key research stories over the year.
🥳 We’d like to thank everyone who took part in, or contributed to our research over 2025!
To learn more >>
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Nutrition, Obesity, Metabolism and Endocrinology

This Theme’s Focus

Theme Leads

Professor Sadaf Farooqi

Professor Nita Forouhi

Our research has six broad sub-themes with the following aims:

Nutrition, Physical Activity, Metabolic Disease and Prevention

Severe Obesity

Type 1 and Type 2 Diabetes

Fatty liver disease and Severe Insulin Resistance

Osteoporosis, Endocrine disorders and Endocrine tumours

Endocrine signals and biomarkers of systemic disease

Latest News

Nutrition, Obesity, Metabolism and Endocrinology Case Studies

Nutrition, Obesity, Metabolism and Endocrinology Publications

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