Imaging

This Theme’s Focus

Developing new, more sensitive imaging methods, especially for MRI (magnetic resonance imaging) and PET (positron emission tomography)
Creating and testing new AI (artificial intelligence) techniques for better imaging and disease detection
Translating these new methods into patient care through collaborations across the UK and with industry

The NIHR Cambridge BRC Imaging theme uses key medical imaging tools to improve:

clinical diagnosis and earlier detection
patient stratification (categorising patients who share similar characteristics)
predicting and detecting response to therapy, and
personalising health care (what to expect for an individual’s disease course).

Improving current medical imaging techniques will have substantial benefits to patients, including those with coronary heart disease, stroke or cancer, improving their outcomes, saving lives and reducing NHS costs. Combining new imaging methods with clinical data, AI techniques and data science will help deliver the NHS Long-Term Plan to diagnose disease earlier and treat it more precisely.

Imaging is central to the diagnosis of many major health conditions, and we are working with themes across the NIHR Cambridge BRC and specialists in academia and industry, from MRI and PET physicists to machine-learning experts in the Cambridge Mathematics of Information in Healthcare Hub (CMIH) and GE Healthcare, to improve diagnosis and prognosis through the integration of information from the patients’ electronic health record (EHR) with advanced image analysis and understanding methods.

We are also involved in several local and national networks, including the National Cancer Imaging Translational Accelerator and the UK7T national network, working together to bring these new imaging techniques to patients in the clinic.

The University of Cambridge Department of Radiology and Wolfson Brain Imaging Centre (WBIC) have a strong track record of clinical research, high-impact publications and academic and industrial collaborations, with over £20 million invested in state-of-the-art equipment since 2017.

Theme Leads

Professor Ferdia Gallagher

Cancer Research UK Senior Research Fellow, Head of the Department of Radiology at the University of Cambridge, and an Honorary Consultant Radiologist at Cambridge University Hospitals
Email: fag1000@cam.ac.uk

Dr Joshua Kaggie

MRI Physicist

Email: jk636@cam.ac.uk

Meet our researchers

Here are some of the areas we are currently investigating:

Pushing the boundaries of imaging technology

Magnetic resonance imaging (MRI) is an excellent diagnostic imaging tool, however examinations can be quite long and costly.

We are developing new techniques to accelerate MRI acquisitions without compromising diagnostic value, combining them with AI to characterise disease more accurately, and using them to advance our understanding of how diseases develop and spread.

Positron emission tomography (PET) is a sensitive tool for imaging normal and abnormal metabolic activity. We are researching new radiotracers that can image specific diseases more accurately. This will help us to improve patient diagnosis and treatment.

Personalised screening

We are developing advanced mathematical techniques to analyse medical images to provide clinicians with more detailed information about particular diseases and their progression, allowing them to refine treatments for patients throughout their care pathway.

We are also investigating new magnetic resonance imaging (MRI) methods that help clinicians to visualise how diseases consume energy to develop.

This process is altered in many diseases – in oncology, for example, we can directly see and quantify the way in which cancers use energy. This allows us to more precisely monitor the effects of anti-cancer therapies.

The right treatment for the right patient

We are developing new imaging methods that allow us to obtain images with higher resolution and better quality, giving clinicians greater confidence in diagnosis.

These new novel methods, combined with advanced mathematical analysis, will help us to diagnose disease earlier, and classify disease more accurately, allowing for more personalised treatment and follow-up.

Advanced imaging combined with therapy is called ‘theranostics’ and our research has shown that using radionuclides (radioactive chemical elements in the body) we can target tumours more accurately.

This has the potential to revolutionise patient management and treatment of many cancers, including renal, prostate, ovary, breast and neuroendocrine cancer.

Working with patients and the public

Do you want to have a say in the cancer imaging research that is important to patients – and should be prioritised?

Or how we raise awareness of research through community outreach?

Or even support study and trial design?

You can do all this and more when you join the Cambridge Radiology and Cancer Imaging PPI group.

Thoughtful woman receiving cancer treatment: Image purchased with lifetime use from Adobe Stock.

This group was set up in March 2025, when researchers from our Imaging theme held a launch event for what is now known as the Cambridge Radiology and Cancer Imaging PPI group.

More than 50 members of the public attended the event, to find out more about why cancer imaging research is so critical and how their involvement can shape the direction of the Cambridge Radiology and Cancer Imaging Programme.

How to join

If you’re interested in cancer imaging research and want to make a difference to the quality of cancer research and patient care, please do consider joining us!

Anyone aged 18+ with experience of cancer imaging as a patient or carer (including friends and family) is welcome to enquire about joining the group.

Download the Cambridge Radiology and Cancer Imaging PPI Group leaflet to find out more about the group.
Watch A Patient’s Perspective: The role of patients in cancer research from the Advanced Cancer Imaging Programme.

Latest News

Celebrating the role of patients in improving radiotherapy services

September 22, 2022

A new display in Addenbrooke’s Hospital highlights how patients have helped shape radiotherapy treatment.

Cambridge researchers awarded Fellow status

May 11, 2022

Eight Cambridge researchers are elected as Fellows of the Academy of Medical Sciences.

Consensus opens door to worldwide improvements in breast cancer radiotherapy treatment

December 30, 2021

A panel of European experts and patients has identified a way to achieve major changes in the way radiotherapy treatment for breast cancer patients is delivered around the world.

Scientists identify the cause of Alzheimer’s progression in the brain

November 1, 2021

New research has used human data to quantify the speed of different processes that lead to Alzheimer’s disease and found that it develops in a very different way than previously thought.

Breast screening - NIHR Cambridge BRC image

New study to test personalised breast cancer screening

October 16, 2024

A new international trial will investigate whether a personalised…

Three nurses looking at a screen - Image from Cambridge University Health Partners

World first for AI and machine learning to treat Covid patients worldwide

October 16, 2024

In a ground-breaking study supported by the NIHR Cambridge…

Well-planned patient preparation before their scans improves imaging quality and cancer detection rates

October 16, 2024

An NIHR Cambridge BRC-supported review of existing studies…

Prostate Cancer Diagnostic Pathways

October 16, 2024

After skin cancer, prostate cancer is the most common cancer…

Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study

July 11, 2022

Association of Collagen, Elastin, Glycosaminoglycans, and Macrophages With Tissue Ultimate Material Strength and Stretch in Human Thoracic Aortic Aneurysms: A Uniaxial Tension Study

June 22, 2022

3 T: the good, the bad and the ugly

November 16, 2021

Federated Learning used for predicting outcomes in SARS-COV-2 patients

September 15, 2021

Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study

March 3, 2021

The NIHR Cambridge BRC is part of the NIHR and hosted by Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge. We are at the heart of the Cambridge Biomedical Campus, Europe’s largest health research area.

Contact Us

Cambridge Biomedical Research Centre
Box 277
Hills Road
Cambridge
CB2 0QQ

Tel: 01223 348490

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13 May

Patient & Public Involvement Showcase is back! This year’s FREE event is bigger & better because we’re teaming up with our partners from across the region. Find out the latest research happening in East of England on 16 June @CUH_NHS! Book: http://bit.ly/NIHREoEPPI26Events

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8 May

Are you a health researcher in East England? Have you used PPI to benefit your research? Tell us about it here (deadline 26 May) & you could be selected to present your research in a poster or short talk at the East of England PPI Showcase, 16 Jun #NIHR20

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8 May

Our PPI Showcase is back! This year’s FREE event is bigger & better because we're joining up with our East of England teams!

📅When: 16 June
📍Where: Jeffrey Cheah Biomedical Centre @CUH_NHS
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7 May

⏰ Three days left to apply to present at the Cambridge NMAP Research Conference by midnight this Sunday!
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Share your work, meet & learn from colleagues across the region.
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7 May

Join us for our East of England Patient & Public Involvement (PPI) showcase on 16 June @CUH_NHS. A FREE event for members of the public & researchers to celebrate how PPI impacts #research. There will be talks, posters & a light lunch. Book http://bit.ly/NIHREoEPPI26Events
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From Wells-next-the-Sea to Southend-on-Sea, are you a health researcher in East England? Tell us how PPI improved your research https://bit.ly/4tLXWgI by 12pm 26 May & you could be invited to present a poster or short talk at the East of England PPI Showcase @CamBioCampus 16 Jun

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Imaging

This Theme’s Focus

Theme Leads

Professor Ferdia Gallagher

Dr Joshua Kaggie

Here are some of the areas we are currently investigating:

Pushing the boundaries of imaging technology

Personalised screening

The right treatment for the right patient

Working with patients and the public

How to join

Latest News

Celebrating the role of patients in improving radiotherapy services

Cambridge researchers awarded Fellow status

Consensus opens door to worldwide improvements in breast cancer radiotherapy treatment

Scientists identify the cause of Alzheimer’s progression in the brain

Imaging Case Studies

New study to test personalised breast cancer screening

World first for AI and machine learning to treat Covid patients worldwide

Well-planned patient preparation before their scans improves imaging quality and cancer detection rates

Prostate Cancer Diagnostic Pathways

Imaging Publications

Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study

Association of Collagen, Elastin, Glycosaminoglycans, and Macrophages With Tissue Ultimate Material Strength and Stretch in Human Thoracic Aortic Aneurysms: A Uniaxial Tension Study

3 T: the good, the bad and the ugly

Federated Learning used for predicting outcomes in SARS-COV-2 patients

Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study

Contact Us

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