Cardiovascular and Respiratory Disease

This Theme’s Focus

Better diagnosis and treatment of heart attacks
Reducing lung infections and injury
Remote diagnosis, monitoring, treatment, and rehabilitation of patients with cardiovascular and respiratory disease

Cardiovascular and respiratory diseases are the leading causes of premature death worldwide – in the UK alone, 1 in 4 of us will die from heart disease and 1 in 5 from lung disease. Half of all deaths from heart disease are sudden and unexpected.

In this theme, we will focus on how we can:

Use existing drugs that are proven in other diseases to treat cardiovascular and respiratory disease (known as ‘repurposing’), resulting in faster approval and wider implementation
Use remote monitoring of patient and community-based programmes to get early patient, public and system benefits via better diagnosis, early intervention, improved uptake and reduced admissions
Develop new drugs that are designed to treat complications of cardiovascular and respiratory disease, including lung infections and heart failure
Combine analysis of patient records and diagnostic tests to improve prediction of disease exacerbations and prevent future events.

Why we need heart and lung research

In this short video, cardiovascular and respiratory theme lead Professor Martin Bennet explains the importance of heart and lung research and how researchers are investigating new ways to treat and prevent diseases.

</p> <p>

Theme Lead

Professor Martin Bennett

BHF Professor of Cardiovascular Sciences and Head of the Section of Cardiovascular and Respiratory Medicine, Department of Medicine.
Email: mrb24@medschl.cam.ac.uk

Meet our researchers

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Here are some of the conditions we are researching:

Heart Attack

The commonest cause of heart attack is atherosclerosis, where arteries become clogged with white fatty substances (plaques). We will develop new drugs to treat the effects of atherosclerosis, and new imaging technologies (such as high-tech scans) to follow high-risk patients and treat them before the plaques rupture. We will also examine how we can better treat and rehabilitate patients with heart failure, where the heart doesn’t pump properly after a heart attack or other forms of damage, and identify new drugs to reduce the damage done with each heart attack.

Lung Disease

In respiratory disease, our focus is lung infection, acute lung injury and bronchiectasis (a long-term condition that makes the lungs more vulnerable to infection). Existing treatments do not slow the progression of the conditions, and patients with chronic lung disease, often have worsening of their disease due to infection. Early diagnosis and treatment of infections can stop patients getting worse, limit the need for antibiotics, prevent patients’ being admitted to hospital, and reduce spread of infections.

Small Vessel Stroke

Strokes caused by blockage of small arteries in the brain are called small vessel strokes, and there is currently no treatment for this form of stroke. We are investigating how commonly used drugs could both prevent small artery stroke and reduce the damage done, reducing the disability from stroke.

Artificial Intelligence-based Analysis of Health Records and Diagnostic Tests

We are examining how computer-based examination of large numbers of patient records, blood tests and new scans can accurately predict outcome in lung infections and heart attacks. This approach can both personalise and target appropriate treatment to specific patients, improving their care and better utilising health resources.

Genetic Analysis

We are using powerful new techniques to examine genetic information from both patients and infections to develop new drugs and reduce the spread of lung infections in patients with chronic cardiovascular and respiratory disease.

Latest News

Global spotlight on Cambridge heart trial

August 22, 2024

A Cambridge trial which may help prevent patients from having repeat heart attacks, will be presented at the 30th European Society of Cardiology (ESC) Congress, the largest cardiology conference globally.

Cambridge launches clinical trial to test new drug for a rare lung condition

January 29, 2024

People with pulmonary sarcoidosis are being invited to take part in an international clinical trial at Cambridge University Hospitals.

Read more about our researchers who have been awarded AMS Fellowships

Researchers awarded prestigious Academy of Medical Sciences Fellowships

May 18, 2023

Four NIHR Cambridge BRC researchers have been elected to the…

Sneezing - Image from Mojpe from Pixabay

Gone fishing: highly accurate test for common respiratory viruses uses DNA as ‘bait’

January 17, 2023

Research supported by NIHR Cambridge BRC has led to a new test…

Patient having their blood test taken at NIHR Cambridge CRF - NIHR Cambridge BRC image

High blood pressure is directly linked to severe COVID-19

November 14, 2022

A new study has shown people with high blood pressure are more likely to be admitted to hospital or die from COVID-19, regardless of other factors such as age, sex, ethnicity or BMI.

Surgery at CUH - Image from Cambridge University Health Partners

Heart surgery delays will cost lives, warns research

June 20, 2022

Urgent action is needed to clear the backlog of people waiting for treatment for severe aortic stenosis as a result of the Covid-19 pandemic.

Cambridge researchers awarded Fellow status

May 11, 2022

Eight Cambridge researchers are elected as Fellows of the Academy of Medical Sciences.

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Cambridge Professors receive NIHR Senior Investigator awards

March 3, 2022

Professor Emanuele Di Angelantonio and Professor Tamsin Ford have been newly-appointed as Senior Investigators for the NIHR.

Man holding his chest - by Pexels from Pixabay

The defibrillator that gets under your skin

October 16, 2024

Sudden cardiac death is a major public health issue occurring…

Genetic study identifies genetic mutations in PAH patients

October 16, 2024

Pulmonary Arterial Hypertension (PAH) is a life-threatening…

Blue helix: This image was purchased from Abobe Stock with a lifetime usage.

Cambridge researchers develop new tool to map beginnings of heart disease

October 16, 2024

Researchers from the Cardiovascular Epidemiology Unit at…

Updated risk model helps doctors predict and prevent cardiovascular disease

October 16, 2024

Cambridge researchers supported by NIHR Cambridge BRC have…

Could a cancer drug be key to helping patients recover from a heart attack?

October 16, 2024

A stage 2 trial is underway in Cambridge to investigate whether…

Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia

December 31, 2018

Publication: Psychological Medicine Fernandez-Egea E, Worbe…

Clinical and demographic correlates of accelerometer-measured physical activity in participants enrolled in the OPTIMISE HFpEF study

December 22, 2021

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

November 26, 2021

Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease

November 25, 2021

SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe

June 15, 2021

Human embryonic stem cell-derived cardiomyocytes express SARS-CoV-2 host entry proteins: screen to identify inhibitors of infection

March 2, 2021

The NIHR Cambridge BRC is part of the NIHR and hosted by Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge. We are at the heart of the Cambridge Biomedical Campus, Europe’s largest health research area.

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Contact Us

Cambridge Biomedical Research Centre
Box 277
Hills Road
Cambridge
CB2 0QQ

Tel: 01223 348490

NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

8 Jul

Our Data Science & Population Health theme with @OTR_Cambridge will hold an in-person 'Software as a Medical Device' workshop from 10am on 13 Nov @CamBioCampus. Including talks from @CogniDox eQMS & @UCamEnterprise. To book email aae35@cam.ac.uk & bg339@cam.ca.uk by 25 July

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NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

7 Jul

How can we help shape the places we live to foster healthy aging?
Watch Dr Louise Lafortune, Principal Research Associate at Cambridge Public Health @Cambridge_Uni talk about aging well in the community.
@CUH_NHS @CamPubHealth @NIHRresearch @louloulaf

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Primary Care Unit, University of Cambridge @pcu_cambridge ·

3 Jul

New guidance helps clinicians talk about uncertain prognoses with older adults facing complex health needs.

Co-designed by researchers & patients, the recommendations aim to improve care of people in uncertain health circumstances.

Read more below:

https://www.phpc.cam.ac.uk/news/cambridge-researchers-provide-new-guidance-clinicians-supporting-older-adults-complex-health-needs

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NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

3 Jul

>> NextGen Researchers - Launch Event!
>> Thursday 10th July - 5-6pm
>> @HLRI_Cambridge
>> Pizza provided 🍕
>> Details on how to book below 👇

@CUH_NHS @Cambridge_Uni @CRUKCamThoracic @CRUKCamCentre @EarlyCancerCam @RoyalPapworth @PCU_Cambridge @NIHRresearch #research

CRUK Cambridge Centre @CRUKCamCentre

Join @CRUKCamThoracic for the launch event of 'NextGen Researchers'. A great opportunity to connect with like-minded early career cancer researchers in Cambridge!

📅 Thurs 10 July, 5-6pm
🍕 Pizza provided
📍@HLRI_Cambridge

Register ➡️ https://zurl.co/ZrFuu @CambridgeBRC

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CRUK Cambridge Centre @crukcamcentre ·

2 Jul

🎧 Our podcast is back! Listen to 'Ask me anything about... the use of artificial intelligence in healthcare' ➡️https://soundcloud.com/crukcamcentre/ama-use-of-artificial-intelligence-in-healthcare

Patient reps ask researchers how AI is being used in cancer research, how it could support personalised treatment, and what the future holds.

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NIHR Cambridge Biomedical Research Centre @cambridgebrc ·

2 Jul

👉 Deadline is 31st July for applications for the Pre-Application Support Fund
👉 Salaried time and support to help you prepare an application for an @NIHRresearch career development award
👉 For more info, check the details below
@CUH_NHS @CUH_NMAresearch @Cambridge_Uni

National Institute for Health and Care Research @NIHRresearch

Applications for the Pre-Application Support Fund close on 31 July.

The scheme is here to help you prepare a strong application for an NIHR career development award. You can get:

➡️ funding for up to 12 months to enhance your NIHR career development application.
➡️ training and…

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Cardiovascular and Respiratory Disease

This Theme’s Focus

Why we need heart and lung research

Theme Lead

Professor Martin Bennett

Here are some of the conditions we are researching:

Heart Attack

Lung Disease

Small Vessel Stroke

Artificial Intelligence-based Analysis of Health Records and Diagnostic Tests

Genetic Analysis

Latest News

Global spotlight on Cambridge heart trial

Cambridge launches clinical trial to test new drug for a rare lung condition

Researchers awarded prestigious Academy of Medical Sciences Fellowships

Gone fishing: highly accurate test for common respiratory viruses uses DNA as ‘bait’

High blood pressure is directly linked to severe COVID-19

Heart surgery delays will cost lives, warns research

Cambridge researchers awarded Fellow status

Cambridge Professors receive NIHR Senior Investigator awards