The NIHR Cambridge BRC has embedded essential infrastructure on the Cambridge Biomedical Campus making sure we translate our world-leading science into real benefits for healthcare.
NIHR BRC-MRC BioRepository
NIHR BRC-MRC BioRepository: Sample Integrity Through Scientific Expertise.
Our high-tech laboratory offers a range of services, including sample receipt, -80°C to +4°C short term-storage, DNA extraction, DNA quality control, re-arraying, automated sample storage, precision automated liquid handling and LIMS.
The NIHR BRC-MRC BioRepository is a modern laboratory based in the centre of Addenbrooke’s Hospital, providing research support for studies and trials on the Cambridge Biomedical Campus. It has expertise in supporting small research projects through to large multi-site national studies where it receives, processes, stores, retrieves blood and other research material. The facility has some of the most advanced automated systems for retrieving and arraying biological material for biomarker applications. In addition to this, it has efficient and cost effective systems for extracting DNA, and can provide a full DNA QC and quantification service. All the material that is processed in the laboratory is entered into a Laboratory Information Management System (LIMS); this provides a full electronic chain of custody for samples. The facility has monitored Ultra Low Temperature Freezers that can be used for short-term storage and a team of five expert staff to provide dedicated research support.
Cambridge is fortunate to have excellent clinical cross-sectional functional imaging facilities with research access to four 1.5T, three 3T Magnetic resonance imaging (MRI) systems, four multi-detector (computed tomography) CTs (16, 64 and 128 multi-detector), dual source and dual energy CT, more than eight colour flow Doppler US systems, several gamma cameras and positron emission tomography (PET)-CT.
The MRC clinical infrastructure funding has provided exciting new opportunities with the upgraded 3T and new 7T MRI, PET-MR and a second clinical hyperpolariser. In addition, an upgraded and extended GMP PET radiopharmaceutical unit with an on-site cyclotron and state-of-the-art radiochemistry systems with the capability of producing a large range of short-lived and longer-lived PET radiotracers. These installations will particularly facilitate and enhance experimental therapeutic trials in dementia, oncology, cardiovascular medicine and within other themes in the Cambridge BRC.
SMCL Next Generation Sequencing (NGS) Hub
The Stratified Medicine Core Laboratory (SMCL) offers researchers access to clinical grade next generation sequencing; a range of platforms to suit all budgets and coverage requirements at short turnaround times. SMCL can provide a complete ‘end to end’ service with a fully flexible approach, encompassing nucleic acid extraction and sample QC, full library preparation and sequencing and bioinformatics analysis or support (or individual parts of this pathway).
The Stratified Medicine Core Laboratory (SMCL) NGS Hub is involved in world class sequencing research partnerships with clients both within the University of Cambridge and the Cambridge University Hospital NHS Foundation Trust, along with further external Academic and Commercial organisations.
The SMCL NGS Hub aims to provide a comprehensive and expert Next Generation Sequencing service to the academic, clinical & commercial community, with the distinctive mission of providing a clinical translational service.
The SMCL NGS Hub is hosted by the Department of Medical Genetics of the University of Cambridge and, uniquely, housed in the Medical Genetics Laboratories of the East Midlands and East of England NHS Genomic Laboratory Hub (East GLH), allowing us to offer researchers access to clinical grade next generation sequencing services.
What can SMCL offer to the academic, clinical and commercial communities?
- SMCL offers researchers access to clinical grade next generation sequencing; a range of platforms to suit all budgets and coverage requirements at short turnaround times.
- SMCL can provide a complete ‘end to end’ service with a fully flexible approach, encompassing nucleic acid extraction and sample QC, full library preparation and sequencing and bioinformatics analysis or support (or individual parts of this pathway).
- SMCL also offers advice on experimental and project design, and can tailor services (e.g., bespoke NGS assays) to specific project needs.
- SMCL’s typical services include:
- Extraction services
- Library Prep
- Clinical Grade Whole Genome Sequencing
- Clinical Grade Whole Exome Sequencing
- Clinical Grade Targeted Sequencing
- Epigenetic analysis (targeted methylation assays, genome wide methylation profiling, RRBS).
- SMCL equipment
- Illumina sequencers
- Illumina cBot
- Agilent Tapestation
- QIAGEN QIAsymphony
- Beckman Coulter Biomek FXP
- Covaris E220 Focused Ultrasonicator
Please visit SMCL website for further details about the facility’s services and equipment.
For quotes and general enquiries, please contact SMCL by email.