Predisposition Footprints in the Somatic Genome of Wilms tumour
Publication: Cancer Discovery
Publication: Cancer Discovery
Publication: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Michal M Graczyk, Rudolf N Cardinal, Tsen Vei Lim, Salvatore Nigro, Elijah Mak, Karen D Ersche
A preference for sooner-smaller over later-larger rewards, known as delay discounting, is a candidate transdiagnostic marker of waiting impulsivity and a research domain criterion. While abnormal discounting rates have been associated with many psychiatric diagnoses and abnormal brain structure, the underlying neuropsychological processes remain largely unknown. Here, we deconstruct delay discounting into choice and rate processes by testing different computational models and investigate their associations with white matter tracts.
Aviva Stafford, Sheri Oduola, Sarah Reeve
Published online 10 September 2024
Publication: BMC Medicine
Chen S, Underwood BR, Cardinal RN, Chen X, Chen S, Amin J, Jin H, Mueller C, Yan LL, Brayne C, Kuper H
26 June 2024
Summary
This was an analysis of pre-existing data from the English Longitudinal Study of Ageing, examining changes over time in risk factors for dementia that have the potential to be altered (such as hypertension, obesity, hearing loss, and social isolation).
Publication: Social Psychiatry and Psychiatric Epidemiology
Kaminska J, Hodgekins J, Lewis JR, Cardinal RN, Oduola S
09 September 2024
Summary
This study examined de-identified NHS data about people having a first episode of psychosis, and looked at how the psychosis began (abruptly or slowly), how long it went untreated, and factors including rural or urban residence. Among such people, some factors differed between rural and urban settings, e.g. employment and living with family. A slow onset of psychosis was associated with a longer time untreated, but rural/urban differences in “time untreated” were not found.
Publication: eClinicaMedicine
Liz Yuanxi Lee j, Delshad Vaghari j, Michael C. Burkhart, Peter Tino, Marcella Montagnese, Zhuoyu Li,
Katharina Zühlsdorff, Joseph Giorgio, Guy Williams, Eddie Chong, Christopher Chen, Benjamin R. Underwood, Timothy Rittman, Zoe Kourtzi
12 July 2024
Summary
Cambridge researchers have developed an artificially-intelligent tool capable of predicting in four cases out of five whether people with early signs of dementia will remain stable or develop Alzheimer’s disease. Read the full press release.
Publication: BJPsych
London SR, Chen S, Sidhom E, Lewis JR, Wolverson E, Cardinal RN, Roalf D, Mueller C, Underwood BR
13 May 2024
Summary
People diagnosed with dementia are often diagnosed in memory clinics and then discharged back to their GP. Some later need intensive mental health support (e.g. crisis teams, or inpatient admission) but others do not. This study shows that it’s possible to predict who will and who won’t, with useful accuracy, based on information collected routinely at the time of initial diagnosis.
Publication: BJPsych
Emilio Fernandez-Egea, Shanquan Chen, Estela Sangüesa, Patricia Gassó, Marjan Biria, James Plaistow, Isaac Jarratt-Barnham, Nuria Segarra, Sergi Mas, Maria-Pilar Ribate, Cristina B García, Naomi A Fineberg, Yulia Worbe, Rudolf N Cardinal, Trevor W Robbins
Summary
This study looked at a group of people treated with clozapine for schizophrenia, examining obsessive-compulsive symptoms (OCS). For some, genetic variants were examined. OCS were common in this group (37.9%). Analysis suggested that both psychosis and clozapine may drive aspects of OCS.
Publication: Nature Neuroscience
Richard Dear, Konrad Wagstyl, Jakob Seidlitz, Ross D. Markello, Aurina Arnatkevičiūtė, Kevin M. Anderson, Richard A. I. Bethlehem, Lifespan Brain Chart Consortium, Armin Raznahan, Edward T. Bullmore & Petra E. Vértes
22 April 2024
Summary
Human brain organization involves the coordinated expression of thousands of genes. For example, the first principal component (C1) of cortical transcription identifies a hierarchy from sensorimotor to association regions. In this study, optimized processing of the Allen Human Brain Atlas revealed two new components of cortical gene expression architecture, C2 and C3, which are distinctively enriched for neuronal, metabolic and immune processes, specific cell types and cytoarchitectonics, and genetic variants associated with intelligence. Using additional datasets (PsychENCODE, Allen Cell Atlas and BrainSpan), we found that C1–C3 represent generalizable transcriptional programs that are coordinated within cells and differentially phased during fetal and postnatal development.
Publication: PNAS
Sofia C. Orellana Richard A. I. Bethlehem, Ivan L. Simpson-Kent and Edward T. Bullmore
9 April 2024
Summary
A new study has found that childhood maltreatment can have an impact into adulthood because of how it effects an individual’s risk of poor physical health and traumatic experiences many years later