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World Health Organisation cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

Publication: The Lancet Global Health

Stephen Kaptoge, Lisa Pennells, Dirk De Bacquer, Marie Therese Cooney, Maryam Kavousi, Oyere Onuma, Mark Woodward, Goodarz Danaei, Gregory Roth, Shanthi Mendis, Ian Graham, Cherian Varghese, Majid Ezzati, Rod Jackson, John Danesh & Emanuele Di Angelantonio

1 September 2019

Summary:

Cambridge-led researchers have updated World Health Organisation (WHO) cardiovascular disease (CVD) risk prediction charts to aid efforts to reduce the burden of CVD, one of the most common non-communicable diseases world-wide and responsible for an estimated 17.8 million deaths in 2017.

The research was funded by the National Institute for Health Research Cambridge Biomedical Research Centre, WHO, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence and UK Medical Research Council.

The revised risk models will help particularly middle- to low-income countries in their efforts to prevent and control CVD. Full story here

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Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

Publication: Nature Biotechnology

Johannes Bargehr, Lay Ping Ong, Maria Colzani, Hongorzul Davaapil, Peter Hofsteen, Shiv Bhandari, Laure Gambardella, Nicolas Le Novère, Dharini Iyer, Fotios Sampaziotis, Florian Weinberger, Alessandro Bertero, Andrea Leonard, William G. Bernard, Amy Martinson, Nichola Figg, Michael Regnier, Martin R. Bennett, Charles E. Murry & Sanjay Sinha

2 August 2019

Summary:

Transplanting an area of damaged tissue with a combination of both heart and muscle cells and supportive cells taken from the outer layer of the heart wall, may be able to help the organs recover from the damage caused by a heart attack. Part funded by the BHF and NIHR and supported by the NIHR Cambridge BRC, researchers have used supportive epicardial cells developed from human stem cells to help transplanted heart cells live longer. Full story here

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A cellular census of human lungs identifies novel cell states in health and in asthma

Publication: Nature Medicine

Felipe A. Vieira Braga, Gozde Kar, Marijn Berg, Orestes A. Carpaij, Krzysztof Polanski, Lukas M. Simon, Sharon Brouwer, Tomás Gomes, Laura Hesse, Jian Jiang, Eirini S. Fasouli, Mirjana Efremova, Roser Vento-Tormo, Carlos Talavera-López, Marnix R. Jonker, Karen Affleck, Subarna Palit, Paulina M. Strzelecka, Helen V. Firth, Krishnaa T. Mahbubani, Ana Cvejic, Kerstin B. Meyer, Kourosh Saeb-Parsy, Marjan Luinge, Corry-Anke Brandsma, Wim Timens, Ilias Angelidis, Maximilian Strunz, Gerard H. Koppelman, Antoon J. van Oosterhout, Herbert B. Schiller, Fabian J. Theis, Maarten van den Berge, Martijn C. Nawijn, Sarah A. Teichmann

17 June 2019

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Summary:

This research carried out a survey of structural and immune cells in the airways of healthy and asthmatic lungs and identified a novel set of T cells resident in asmatic airways. There is altered communication between immune and structural cells in asthmatic airways and these changes underlie the inflammation in these airways.

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Quantifying normal human brain metabolism using hyperpolarized [1-(13)C]pyruvate and magnetic resonance imaging

Publication: Neuroimage

Grist JT, McLean MA, Riemer F, Schulte RF, Deen SS, Zaccagna F, et al.

1 April 2019

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Detection and Prediction of Bioprosthetic Aortic Valve Degeneration

Publication: Journal of the American College of Cardiology Volume 73, Issue 10, 19 March 2019, Pages 1107-1119

Cartlidge TRG, Doris MK, Sellers SL, Pawade TA, White AC, Pessotto R, Kwiecinski J, Fletcher A, Alcaide C, Lucatelli .

19 March 2019

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An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors.

Publication: J Proteome Res

Harshfield EL, Koulman A, Ziemek D, Marney L, Fauman EB, Paul DS, et al.

19 March 2019

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Stiffening and ventricular-arterial interaction in the ascending aorta using MRI: ageing effects in healthy humans

Publication: Journal of Hypertension

Li Y, Hickson SS, McEniery CM, Wilkinson IB, Khir AW.

February 2019

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New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Publication: Nature Genetics

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, et al.

25 February 2019

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Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study.

Publication: Lancet

Lord J, McMullan DJ, Eberhardt RY, Rinck G, Hamilton SJ, Quinlan-Jones E, et al. Lancet.

23 February 2019

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Pulmonary hypertension in chronic lung disease and hypoxia

Publication: European Respiratory Journal

Nathan SD, Barbera JA, Gaine SP, Harari, S, Martinez FJ, Olschewski H, Olsson KM, Peacock AJ, Pepke-Zaba J, Provencher S, Weissmann N, Werner Seeger W.

13 December 2018

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New guidance helps clinicians talk about uncertain prognoses with older adults facing complex health needs.

Co-designed by researchers & patients, the recommendations aim to improve care of people in uncertain health circumstances.

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https://www.phpc.cam.ac.uk/news/cambridge-researchers-provide-new-guidance-clinicians-supporting-older-adults-complex-health-needs

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