Scientists confirm precursor to commonest form of oesophageal cancer – offering opportunities to catch the disease early
Professor Rebecca Fitzgerald – Photo credit: Stillvision
16 April 2026
Scientists have found the strongest evidence to date that a condition known as Barrett’s oesophagus is the starting point for all cases of oesophageal adenocarcinoma – the most common type of oesophageal cancer in the developed world – even when telltale signs of this pre-cancerous stage are no longer visible.
The findings, published today in Nature Medicine, could help improve screening for and early detection of oesophageal cancer, the sixth most deadly cancer, helping improve outcomes for the disease.
Cancer of the oesophagus, including its most common form oesophageal adenocarcinoma (OAC), is on the rise in western countries. It is difficult to treat because it is often caught at an advanced stage, when treatment options are limited.
Scientists and doctors have known for some time that the development of oesophageal cancer is linked with Barrett’s oesophagus, which shows up in endoscopy as a pink patch in the surface of the oesophagus. Barrett’s oesophagus affects around one out of every 100 to 200 people in the United Kingdom.
Between three and 13 people out of 100 with Barrett’s oesophagus will go on to develop oesophageal adenocarcinoma in their lifetime. However, around half of OAC patients have no detectable Barrett’s oesophagus when their cancer is found, raising doubts about whether it is always the precursor.
Professor Rebecca Fitzgerald, pictured above, from the Li Ka Shing Early Cancer Institute at the University of Cambridge said: “Cancer generally takes many years to evolve, giving us a window of opportunity to catch it before if develops into a life-threatening condition. Screening and preventative strategies can have a massive impact on the number of people who die from cancer, but if the link between precancers and cancer is unproven or unclear, screening programmes risk doing more harm than good.”
