Deconstructing delay discounting in human cocaine addiction using computational modelling and neuroimaging
Publication: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Michal M Graczyk, Rudolf N Cardinal, Tsen Vei Lim, Salvatore Nigro, Elijah Mak, Karen D Ersche
A preference for sooner-smaller over later-larger rewards, known as delay discounting, is a candidate transdiagnostic marker of waiting impulsivity and a research domain criterion. While abnormal discounting rates have been associated with many psychiatric diagnoses and abnormal brain structure, the underlying neuropsychological processes remain largely unknown. Here, we deconstruct delay discounting into choice and rate processes by testing different computational models and investigate their associations with white matter tracts.