The NHS England 100,000 Genomes Project – Feasibility and utility of centralised genome sequencing for children with cancer

Publication: British Journal of Cancer

Jamie Trotman, Ruth Armstrong, Helen Firth, Claire Trayers, James Watkins, Kieren Allinson, James C. Nicholson, G. A. Amos Burke, Sam Behjati, Matthew J. Murray, Catherine E. Hook, Patrick Tarpey

22 April 2022


Summary

As part of the national 100,000 Genome Project, researchers recruited from 36 children, across 23 different solid tumour types. Whole genome sequencing (WGS) data from paired tumour (fresh-frozen tissue) and matched normal (blood) samples was analysed.  The results for each case were clinically reviewed at the Cambridge paediatric oncology Genomic Tumour Advisory Board (GTAB), and formal report of the results was written.

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