Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity
Publication: Medrxiv
EJ Needham, AL Ren, RJ Digby, JG Outtrim, DA Chatfield, AE Manktelow, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslen, A Edén, E Marklund, MJ Griffiths, J Cavanagh, G Breen, View ORCID ProfileSR Irani, A Elmer, N Kingston, JR Bradley, LS Taams, View ORCID ProfileBD Michael, ET Bullmore, KGC Smith, PA Lyons, AJC Coles, DK Menon, the Cambridge Neuro COVID Group, the NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility
5 December 2021
Summary
COVID-19 has been associated with many neurological complications including stroke, delirium and encephalitis. But it is unknown the full neurological injury Covid-19 has caused.
Researchers investigated the dynamics of, and relationship between, serum markers of brain injury and markers of dysregulated host response including measures of autoinflammation (proinflammatory cytokines) and autoimmunity.
