Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
Publication: Nature Metabolism
Scott C. Ritchie, Samuel A. Lambert, Matthew Arnold, Shu Mei Teo, Sol Lim, Petar Scepanovic, Jonathan Marten, Sohail Zahid, Mark Chaffin, Yingying Liu, Gad Abraham, Willem H. Ouwehand, David J. Roberts, Nicholas A. Watkins, Brian G. Drew, Anna C. Calkin, Emanuele Di Angelantonio, Nicole Soranzo, Stephen Burgess, Michael Chapman, Sekar Kathiresan, Amit V. Khera, John Danesh, Adam S. Butterworth & Michael Inouye
8 November 2021
Summary
For the first time, scientists have used polygenic scoring to identify molecular drivers of cardiovascular disease and diabetes, which could be targeted to help prevent or treat some of these conditions.