Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations

Publication: Circulation: Genomic and Precision Medicine

Danielle E. Haslam, Gina M. Peloso, Melanie Guirette, Fumiaki Imamura, Traci M. Bartz, Achilleas N. Pitsillides, Carol A. Wang, Ruifang Li-Gao, Jason M. Westra, Niina Pitkänen, Kristin L. Young, Mariaelisa Graff, Alexis C. Wood, Kim V.E. Braun, Jian’an Luan, Mika Kähönen, Jessica C. Kiefte-de Jong, Mohsen Ghanbari, Nathan Tintle,  Rozenn N. Lemaitre, Dennis O. Mook-Kanamori, Kari North, Mika Helminen, Yasmin Mossavar-Rahmani, Linda Snetselaar, Lisa W. Martin, Jorma S. Viikari, Wendy H. Oddy, Craig E. Pennell, Frits R. Rosendall, M. Arfan Ikram, Andre G Uitterlinden, Bruce M. Psaty, Dariush Mozaffarian, Jerome I. Rotter, Kent D. Taylor, Terho Lehtimäki, Olli T. Raitakari, Kara A. Livingston, Trudy Voortman, Nita G. Forouhi, Nick J. Wareham, Renée de Mutsert, Steven S. Rich, JoAnn E. Manson, Samia Mora, Paul M. Ridker, Jordi Merino, James B. Meigs, Hassan S. Dashti, Daniel I. Chasman, Alice H. Lichtenstein, Caren E. Smith, Josée Dupuis, Mark A. Herman, Nicola M.McKeown

16 July 2021


Summary

ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. Researchers investigated  that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia (an abnormal level of cholesterol and other lipids, also called fats, in the blood).

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