Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations
Publication: Circulation: Genomic and Precision Medicine
Danielle E. Haslam, Gina M. Peloso, Melanie Guirette, Fumiaki Imamura, Traci M. Bartz, Achilleas N. Pitsillides, Carol A. Wang, Ruifang Li-Gao, Jason M. Westra, Niina Pitkänen, Kristin L. Young, Mariaelisa Graff, Alexis C. Wood, Kim V.E. Braun, Jian’an Luan, Mika Kähönen, Jessica C. Kiefte-de Jong, Mohsen Ghanbari, Nathan Tintle, Rozenn N. Lemaitre, Dennis O. Mook-Kanamori, Kari North, Mika Helminen, Yasmin Mossavar-Rahmani, Linda Snetselaar, Lisa W. Martin, Jorma S. Viikari, Wendy H. Oddy, Craig E. Pennell, Frits R. Rosendall, M. Arfan Ikram, Andre G Uitterlinden, Bruce M. Psaty, Dariush Mozaffarian, Jerome I. Rotter, Kent D. Taylor, Terho Lehtimäki, Olli T. Raitakari, Kara A. Livingston, Trudy Voortman, Nita G. Forouhi, Nick J. Wareham, Renée de Mutsert, Steven S. Rich, JoAnn E. Manson, Samia Mora, Paul M. Ridker, Jordi Merino, James B. Meigs, Hassan S. Dashti, Daniel I. Chasman, Alice H. Lichtenstein, Caren E. Smith, Josée Dupuis, Mark A. Herman, Nicola M.McKeown
16 July 2021
Summary
ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. Researchers investigated that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia (an abnormal level of cholesterol and other lipids, also called fats, in the blood).