Low dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial
Publication: The American Journal of Clinical Nutrition
07 April 2021
Summary
Thiamine (vitamin B1) is essential for normal growth, development and energy metabolism. Thiamine is found in a wide-range of foods and deficiency is not usually a problem with a varied diet. However, in some populations, with diets that consist mostly of thiamine-poor white, polished rice, there may be an increased risk of thiamine deficiency.
The NIHR Cambridge BRC Nutritional Biomarker Laboratory was responsible for the blood analysis of two thiamine biomarkers for a recently published study led by Dr Kyly Whitfield (Mount Saint Vincent University, Canada). The aim of the study was to investigate the amount of supplemental thiamine intake required to optimise breastmilk thiamine concentrations and mother and infant blood thiamine status.
In the study, 335 mothers in rural Cambodia were randomised to one of four daily thiamine supplementation doses (0, 1.2, 2.4, or 10 mg per day) from 2 weeks to 6 months postpartum. At the end of the intervention period, blood samples were collected from mothers and infants, and breastmilk from mothers to estimate the optimal thiamine dose to improve thiamine status.
The results showed that women taking any of the thiamine-containing supplements had significantly higher thiamine content in their milk compared to the placebo group. Both mothers and infants had improved blood thiamine status after supplementation. In the study, a dose of 1.2 mg thiamine/day improved the thiamine status of breastfeeding mothers and their infants, normalising thiamine status, and may reduce the risk of thiamine deficiency and infantile beriberi. We hope the results of this study will inform a future thiamine fortification program in Cambodia, and elsewhere in South and Southeast Asia where thiamine deficiency remains a public health concern.
