Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial
Publication: The American Journal of Clinical Nutrition
Gallant, J., Chan, K., Green, T., Wieringa, F., Leemaqz, S., Ngik, R., Measelle, J., Baldwin, D., Borath, M., Sophonneary, P., Yelland, L., Hampel, D., Shahab-Ferdows, S., Allen, L., Jones, K., Koulman, A., Parkington, D., Meadows, S., Kroeun, H. and Whitfield, K.
7 April 2021
Infantile beriberi–related mortality is still common in South and Southeast Asia. Interventions to increase maternal thiamine intakes, and thus human milk thiamine, are warranted; however, the required dose remains unknown.
Healthy mothers were recruited in Kampong Thom, Cambodia. At 2 wk postpartum, women were randomly assigned to consume 1 capsule, containing 0, 1.2 (estimated average requirement), 2.4, or 10 mg of thiamine daily from 2 through 24 weeks postpartum.
Human milk total thiamine concentrations were measured and maternal and infant blood thiamine biomarkers were also assessed.