Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

Publication: Brain

Claire O’Callaghan, Frank H Hezemans, Rong Ye, Catarina Rua, P Simon Jones, Alexander G Murley, Negin Holland, Ralf Regenthal, Kamen A Tsvetanov, Noham Wolpe, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Rowe

30 March 2021


Summary:

Drugs that increase the brain’s noradrenaline can improve cognition in Parkinson’s disease. A challenge remains to identify those who will most benefit from noradrenergic drugs. We show that drug response depends on integrity of the locus coeruleus nucleus. This will inform clinical trial patient selection and treatment.

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