Somatic Evolution in Non-neoplastic IBDAffected Colon

Publication: Cell

Olafsson S, McIntyre RE, Coorens T, Butler T, Jung H, Robinson PS, Lee-Six H, Sanders MA, Arestang K, Dawson C, Tripathi M. Somatic evolution in non-neoplastic IBD-affected colon.

6 August 2020


Summary

Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts (intestinal glands in the colon) from 46 IBD patients and compared these to 412 crypts from 41 non-IBD controls from our previous publication on the mutation landscape of the normal colon.

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