Somatic Evolution in Non-neoplastic IBDAffected Colon
Publication: Cell
Olafsson S, McIntyre RE, Coorens T, Butler T, Jung H, Robinson PS, Lee-Six H, Sanders MA, Arestang K, Dawson C, Tripathi M. Somatic evolution in non-neoplastic IBD-affected colon.
6 August 2020
Summary
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts (intestinal glands in the colon) from 46 IBD patients and compared these to 412 crypts from 41 non-IBD controls from our previous publication on the mutation landscape of the normal colon.