In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies

Publication: Neurobiology of Ageing

ElijahMaka, NeginHolland, P. Simon Jones, George Savulich, Audrey Lowa, Maura Malpetti, Sanne Kaalund, Luca Passamonti, Timothy Rittman, Rafael Romero-Garciaa, Roido Manavakic, Guy B.Williams, Young T.Hong, Ti m D. Fryerb, Franklin I. Aigbirhio, John O’Brien, James Rowe

30 January 2021


Summary

Researchers found in neurodegenerative disorders of Progressive Supranuclear Palsy and Corticobasal Degeneration, the core communication units of the brain (present on nerve cell ‘bodies’ and ‘tails’) are tightly coupled together and are both significantly reduced by the disease process. The research shows changes in the brain of patients with neurodegenerative disorders and can help inform the design of clinical trials

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