Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study

Publication: Neurology

Marios K. Georgakis, Eric L. Harshfield, Rainer Malik, Nora Franceschini, Claudia Langenberg, Nicholas J. Wareham, Hugh S. Markus, Martin Dichgans

25 January 2021


The researchers employed Mendelian randomization to explore the effects of genetic predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and pancreatic β-cell dysfunction on risk of stroke subtypes and related cerebrovascular phenotypes.

This study supports causal effects of T2D and hyperglycemia on large artery and small vessel stroke. Genetically predicted insulin resistance and β-cell dysfunction are associated with large artery and small vessel stroke; this may have implications for antidiabetic treatments targeting these mechanisms.

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