Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study
Publication: The American Journal of Clinical Nutrition
Zheng J, Imamura F, Sharp SJ, Koulman A, Griffin JL, Mulligan AA, et al.
17 April 2019
Little is known about changes in blood fatty acid compositions over time and the correlates of any changes in a general population.
The aim of this study was to estimate changes in 27 individual plasma phospholipid fatty acids and fatty acid groups over time, and to identify potential correlates of these changes, using profiles from 722 participants in the European Prospective Investigation into Cancer and Nutrition-Norfolk Study, UK.
Changes in fatty acid levels were associated with consumption of different food groups. For example, a mean 100 g/d increase in fatty fish intake was associated with a 19.3% greater annual increase in marine n–3 PUFAs.
Even-chain SFAs and TFAs declined and marine n–3 PUFAs increased over time. These changes were partially explained by changes in dietary habits, and could potentially help interpret associations of baseline fatty acid composition with future disease risk.