Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries
Publication: Diabetologia
Sherly X. Li, Fumiaki Imamura, Matthias B. Schulze, Jusheng Zheng, Zheng Ye, Antonio Agudo, Eva Ardanaz,
Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Sara Grioni, Marc J. Gunter,
José María Huerta, Daniel B. Ibsen, Marianne Uhre Jakobsen, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw,
Cecilie Kyrø, Francesca Romana Mancini, Elena Molina-Portillo, Neil Murphy, Peter M. Nilsson, N. Charlotte Onland-Moret, Domenico Palli, Salvatore Panico, Alaitz Poveda, J. Ramón Quirós, Fulvio Ricceri, Ivonne Sluijs,
Annemieke M. W. Spijkerman, Anne Tjonneland, Rosario Tumino, Anna Winkvist, Claudia Langenberg, Stephen J. Sharp, Elio Riboli, Robert A. Scott, Nita G. Forouhi & Nicholas J. Wareham
17 March 2018
Summary
Researchers investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases).